Whether this effect is related to the dose or concentration at steady state (Css) of VPA is yet to be established
The brand-name form of valproic acid in the United States and Canada is Depakene
30, 31 However, smaller open-label studies have shown much higher efficacy rates for lamotrigine than the rates observed in our study, despite similarities in dose ranges Both valproic acid and lamotrigine are effective as first-line monotherapy for the treatment of newly diagnosed adults with idiopathic generalized tonic-clonic seizures but valproic acid is preferable to lamotrigine because of being more effective and safe
2%, respectively, has been shown in women using very-low-dose COCs, VPA chronic therapy or VPA overdose produces L-carnitine (LCAR) depletion, and this could impair β -oxidation leading to the ω -oxidation pathway and the formation of toxic metabolites
The intensity of this adverse effect can vary from transient mild rash to
Valproic acid may cause serious or life-threatening damage to the liver that is most likely to occur within the first 6 months of therapy
This effect of valproate is dose-dependent
3Valproic acid is an inhibitor of lamotrigine glucuronidation For patients taking valproic acid regardless of any concomitant medication, a more cautious titration scheduleis available than that detailed in Table 1
At week 5 and beyond, may increase by 100 mg/day PO q1-2Week to 300-500 mg/day PO divided q12hr
[5,7] We report a case with SJS likely induced by the use of a lamotrigine and valproic acid regimen and as a dental Introduction
The use of combined oral contraceptive pills (OCPs) with lamotrigine has been shown to reduce lamotrigine concentrations by 50%, increasing the risk of seizures
Methods: We prospectively recorded our experience in adding LTG to VPA-containing regimens in 108 patients