5mL/kg/dose (to a maximum of 20mL) 12 hourly for 3 days OR 8mg/kg/dose (to a maximum of 320mg) given once daily for 5 days
Skin and Soft-Tissue Infections in Community-Associated MRSA
In vitro evidence suggests TMP/SMX has greater bactericidal activity against community-acquired MRSA than linezolid (Zyvox), rifampin (Rifadin), clindamycin
Blood culture Treatment For a local skin MRSA infection, draining the abscess at the doctor's office is usually the only treatment needed
Over the last 2 decades
Using concealed allocation, the investigators randomized the patients to
Acute bacterial skin and skin-structure infections (ABSSSIs) are commonly encountered infections in various healthcare settings []
Oral dosage in adults and children weighing 40 kg (88 pounds) or more should have a single tablet of 800 mg of sulfamethoxazole and 160 mg of trimethoprim every 12 hours for 10 to 14 days
CrCl < 10 mL/min: The usual dose should be administered every 24 hours
Sulfonamides should be given with caution to patients with impaired renal or hepatic function
This product is available in the following dosage forms: Dr
For most patients with cellulitis who don't have features that warrant specific management, our approach depends on the severity of illness, patient's immune status, and risk for MRSA, as outlined below and in the algorithm (algorithm 1)
PJP treatment: 15–20mg/kg per day What Is Bactrim? Bactrim (sulfamethoxazole and trimethoprim) I
risk of methemoglobinemia (additive effects) methenamine
Executive summary
Sulfamethoxazole is N1-(5-methyl-3-isoxazolyl)sulfanilamide; the molecular formula is C10H11N3O3S
(3, 9) Plus folic acid 2
Prophylaxis: 2 mg TMP/kg/dose PO qDay or 5 mg TMP/kg/dose twice weekly Skin/soft Tissue Infection Due to Community Acquired MRSA (Off-label) 8-12 mg TMP/kg/day PO divided q12hr for 5-10 days; add beta-lactam antibiotic to regimen if beta-hemolytic Streptococcus spp also suspected Type of Infection
When used to treat cutaneous CA-MRSA infections, a daily doxycycline dose of 200mg per day is generally used
Many experts recommend higher doses (8-10 mg/kg daily) for MRSA bacteremia and endocarditis