A recent before and after study in CHEST (June 2017) of IV vitamin C, thiamine, and hydrocortisone suggested a remarkable mortality benefit in patients with sepsis
For one thing, people with sepsis tend to have surprisingly low
Small interventional studies have indicated that administration of gram doses of vitamin C to patients with pneumonia and sepsis improves organ function and potentially decreases
Measurement of hepatic vitamin A levels
In particular, vitamin C-containing regimens as adjunctive therapy in sepsis have received much attention
As sepsis treatment, it has recently been the subject of intense research
This study aimed to investigate the effect of adjunctive intravenous high-dose vitamin C treatment on hospital mortality in patients with sepsis
A previous study showed that patients with sepsis need 3 g/day of vitamin C to reach normal
“These data do not support routine use of this combination therapy for patients with septic shock,” the ACTS study researchers concluded
Materials and methods: A systematic review was conducted on PubMed, Embase, and the Central Cochrane Registry
Vitamin C is an important anti-oxidant and an enzyme cofactor for many important biological reactions
RATIONALE FOR VITAMIN C THERAPY IN SEPSIS
The addition of thiamine and To further explore the potential of vitamin C as a treatment for sepsis, researchers conducted a systemic review search of PubMed, Embase, and Central Cochrane Registry, which yielded 21 prospective, randomized clinical trials in which vitamin C was used as an intervention for a total of 2548 adult patients with sepsis
Vitamin C could attenuate sepsis-associated lung injury by preventing sepsis-induced cytokine storms and neutrophil accumulation
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Function
Electronic databases were searched from inception to August 2019 for the studies comparing the effect of vitamin C versus non-vitamin C infusion in patients with sepsis
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