CC acts by competing with endogenous circulating estrogens for estrogen receptor binding sites on the hypothalamus , thereby blocking the negative feedback of endogenous estrogen
Contraindications (i) Absorption: In early radiolabeled clinical studies, research has shown that clomiphene citrate is readily absorbed orally
clomiPHENE Pharmacokinetics Absorption Bioavailability
Published: 01 March 1973 Article history PDF Split View Cite Permissions Share Abstract Plasma luteinizing hormone (LH) was measured by radioimmunoassay at 20-min
Total testosterone increased with 2
Twenty-four healthy adult female volunteers participated in a randomized, three phase double-blind crossover trial comparing the
Uncommon, but potentially severe adverse events include
All three doses of enclomiphene citrate increased the testosterone concentration at time 0 of each 24-h sampling period, and the mean, maximum
Most testosterone, about 90%, is excreted in the urine as glucuronic or sulfuric
Clomiphene citrate is capable of interacting with estrogen-receptor-containing tissues, including the hypothalamus, pituitary, ovary, endometrium, vagina, and cervix
Higher doses of clomiphene can also lead to visual disturbances, which may be irreversible, or a condition called ovarian hyperstimulation syndrome (OHSS)
Adverse effects Clomiphene citrate, of which enclomiphene citrate is derived from, is a drug approved by the Food and Drug Association (FDA) for indications of anovulatory or oligo-ovulatory infertility and male Clomiphene Citrate 50mg Tablet (49884-0701) (Par Pharmaceuticals, an Endo Company) null The half-life of clomiphene is reported to be 5 days, but studies with radiolabeled doses have demonstrated that the drug may be found in the feces for up to 6 weeks
BJU FAQs
Clomiphene (or clomiphene citrate) Based on a single-dose healthy volunteer clinical study, it is evident that zuclomiphene has a longer half-life than enclomiphene and may remain longer than a month in these volunteers
Clomid (clomiphene citrate) causes an increase in the production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)
As a general rule, it takes five half lives for a drug to begin to have its full effect,” Jandes explains
The rather long plasma half-life (approximately 5 to 7 days) is due largely to plasma protein binding, enterophepatic circulation, and accumulation in fatty tissues
Subsequent single-dose studies in normal volunteers showed that zuclomiphene (cis) has a longer half-life than enclomiphene (trans)
The conventional model-dependent pharmacokinetics of clomiphene citrate isomers could not be determined due to a very flat terminal half-life and the long-tailed residence time, signifying the lipophilic nature and potentially extensive distribution of the compound
Subsequent single-dose studies in normal volunteers showed that zuclomiphene (cis) has a longer half-life than enclomiphene (trans)
Zuclomiphene, a weak estrogen receptor agonist, is another isomer of clomiphene citrate
In our opinion, clomiphene citrate is a potential effective and safe treatment and should be considered as a therapy in men with symptomatic hypogonadism