Hydroxyurea (HU) is a water-soluble antiproliferative agent used for decades in neoplastic and nonneoplastic conditions
1126/science
In healthy volunteers
Hydroxyurea (HU), also called hydroxycarbamide, is a simple hydroxylated compound with the molecular formula CH 4 N 2 O 2, structurally an analog
The mechanism of the salutary effect of hydroxyurea is largely attributable to its ability to
Hydrea (hydroxyurea) is a prescription capsule that treats chronic myeloid leukemia and skin cancer of the head and neck
Objectives: The aims of this review are to determine through a review of randomised or
HbF is better than other types of hemoglobin at carrying oxygen around the body
Inhibits ribonucleotide reductase
Abstract
As the main mechanism of action of hydroxyurea is inhibition of rNDP enzyme, thus arresting cells at G1 or S phase of the cell cycle, bone marrow suppression is commonly associated with its treatment
Hydroxyurea was first synthesised in the 1860s, but its use as a cancer therapy was not reported until 1960
17 As an example, the mechanism of the peroxidase-mediated formation of nitric oxide from dismutation of the hydroxyurea nitroxide radical, followed by hydrolysis of a nitroso derivative intermediate Hydroxyurea (HU) is a water-soluble antiproliferative agent used for decades in neoplastic and nonneoplastic conditions
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Clinical safety, hematological efficacy, risk of carcinoma or leukemia, and frequency of progression to
Hydroxyurea was embryotoxic and teratogenic in rats and rabbits at doses 0