Results: Longer treatments, but not higher weekly fluconazole doses, resulted in better cure rates for toenail, and possibly fingernail, onychomycosis
Continuing Education Activity
When treating patients with onychomycosis, much smaller dosages have been used: 150 to
Aditya K
Evidence-based optimal fluconazole dosing regimen for onychomycosis treatment
Fluconazole is active in vitro against the most common pathogens of onychomycosis, penetrates into the nail bed, and is clinically effective in the treatment of a wide variety of superficial fungal infections
Less common therapeutic interventions include fluconazole (off-label use), laser therapy, photodynamic therapy, and surgical nail removal
Abstract
This regimen is not approved for either toenail or fingernail onychomycosis
A total of 30 studies were included in the systematic review, while 22 Topical antifungal agents are effective in treating onychomycosis, with a number needed to treat (NNT) of 7 to 17
Fluconazole is thought to be equally effective in candidal onychomycosis and can be used at the dosage of 50 mg daily or as pulse therapy at the dosage of 300 mg per week
The usual dosage of fluconazole for onychomycosis is 150 mg once weekly for 6 months for fingernails, and 12 months for toenails [ 79 ]
An abnormal nail not caused by a fungal infection is a dystrophic nail
albicans infections
Salo H, Pekurinen M
In the elderly, onychomycosis may have an
Onychomycosis is a chronic infection of the nail unit, and its prevalence increases with age
Tinea unguium most frequently targets your toenails, but it can also affect your fingernails
Oral 150 – 450 mg once weekly for 3 months (fingernail) or 6 – 12 months (toenail) 5
2023 Jul-Dec;22 (12):1169-1178
Oral antifungals are used for the treatment of moderate-severe onychomycosis
See Fluconazole for dosing and lab monitoring; Dosing