We describe a relatively rare adverse effect of amiodarone in our case report of a 61-year-old man, who was electively admitted for implanted cardioverter
Case
Case Presentation A 76-year-old-woman with a history of atrial fibrillation, sick sinus syndrome, ischemic cardiomyopathy, and
It develops over years of use of amiodarone and can lead to discontinuation of the drug
A 45-year-old man had severe blue-gray cutaneous discoloration during amiodarone therapy for atrial fibrillation
Amiodarone can cause multiple organ dysfunction including liver and renal failure, hyperthyroidism, parkinsonism, and blue-man syndrome
Medicine
A much less common adverse reaction is the so-called “Blue man syndrome,” occurring
It is rarely seen today, as patients are educated to take precautions to avoid exposure to direct sunlight
The most dramatic symptom of argyria is that the skin turns blue or blue-gray
We describe a rare case of amiodarone induced blue-gray skin discoloration
Ammoury A, Michaud
Dose-dependent appearance and disappearance of amiodarone-induced skin pig-mentation
Its incidence ranges from 2-57%
com, a low blood pressure
Blue man syndrome is thought to stem from the deposition of lysosomal membrane-bound dense The incidence of blue-gray skin discoloration in children is estimated <2% 4
Blue-gray cutaneous discoloration, also known as blue man syndrome, is an undesirable and unusual side-effect of chronic amiodarone therapy in less than 3% of patients
Amiodarone is one of the most commonly used and effective antiarrhythmic drugs to treat ventricular and supraventricular arrhythmias
Amiodarone is increasingly used in cardiology due to convenient dosing, low frequency of pro-arrhythmic effects, and good short term tolerance without significant hypotension
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