Also the concentration stays higher over time as well
Sublingual Tablet – We recommend taking estradiol tablets sublingually, which means to let it dissolve under the tongue rather than
It has been debated whether sublingual administration of estradiol
[2] [36] [37] This is due to the fact that estradiol is poorly soluble in water, which limits its dissolution and absorption, and is additionally
Swallowing them directly does force your liver to bear an additional metabolic load, once
Purpose: Maintaining cross-sex hormone levels in the normal physiologic
HRT estradiol question sublingual or swallow
Sublingual administration involves placing a drug under your tongue to dissolve and absorb into your blood through the tissue there
Many people on this sub will tell you that Estrone is a "weaker" estrogen and can take up estrogen receptors that would be better served by estradiol
buccal is easier
ago
My doctor says as long as it dissolves it's fine, but I'm trying to maximize the amount that is absorbed through the membranes in my mouth before I swallow any that escapes
It's typically oval shaped or tiny pellet (depending on brand)
Even though sublingual and buccal absorption of estrogen is relatively rapid, troches dissolve more slowly than tablets (from
A quick tip about sublingual estrogen
Any liver processing that sublingual estradiol goes through, any estradiol in the blood should go through
MyClosetedBiAlt • 1 yr
“up to 2 mg/day E2 valerate is administered in single daily doses taken in the morning, whereas the maximum dose of 6 mg/day is given on days 10-13, as three equal doses, morning, noon and evening
Reply Inside your mouth, under the tongue or between the teeth and gums
It depends on the way it is packaged so it is probably best to follow the directions on the bottle