Drug interactions are reported among 313 people who take Metformin hydrochloride and Plaquenil
Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan
Grapefruit juice can significantly increase the blood levels and effects of hydroxychloroquine, which may result in an irregular heart rate or other conduction disturbances
Major: Highly clinically significant
Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco
Avoid combinations; the risk of the interaction outweighs the benefit
Ritonavir, a strong cytochrome P450 (CYP) 3A4 inhibitor and a P-glycoprotein (P-gp) inhibitor, is coadministered with nirmatrelvir to increase the blood concentration of nirmatrelvir, thereby making it effective against SARS-CoV-2
The relevance of a particular drug interaction to a specific individual is difficult to determine
With this type of diabetes, insulin produced by the pancreas is not able to get sugar into the cells of the body where it can work properly
Major: Highly clinically significant
You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with hydroxychloroquine
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances
Common side effects may include: This is not These classifications are only a guideline
Moderate Drug interaction risk between cardioprotective drugs and drugs used in treatment of COVID-19: A evidence-based review from six databases hydroxychloroquine, and ivermectin
There is an emerging evidence that suggests its beneficial effect against diabetes mellitus
A recent experimental study has suggested an increased toxicity of hydroxychloroquine in association with metformin in mice
Always consult your healthcare provider before starting or stopping any medication
Grapefruit or grapefruit juice, especially if consumed in large amounts, can cause additive QT interval prolongation when taken with QT interval-prolonging drugs, potentially increasing the risk of ventricular arrhythmias
Unknown: No interaction information available
Always consult your healthcare provider before starting or stopping any medication
Hydroxychloroquine (Plaquenil) is taken by mouth, typically once or twice per day
Unknown: No interaction information available
CellCept disease interactions Another recent preprint indicates that hydroxychloroquine can interact with the diabetes medication metformin in mice
Low blood sugar, or hypoglycemia, is more likely with this interaction
A New Drug-Drug Interaction Between Hydroxychloroquine and Metformin? A Signal Detection Study
Our study identified a signal for the association hydroxychloroquine + metformin that appears to be more at risk of fatal outcomes (particularly by completed
To determine the
Prevention Talk with your doctor Plaquenil (hydroxychloroquine) is a prescription drug that treats and prevents malaria