In the only randomized, double-blind, placebo-controlled study that assessed the cardiovascular implications of combining clopidogrel and omeprazole, patients
Omeprazole and esomeprazole are inhibitors of this enzyme meaning concurrent use can reduce plasma levels of activated clopidogrel
Examples include certain acid reducers (proton pump inhibitors/PPIs such as omeprazole, esomeprazole), cimetidine, etravirine, felbamate, fluconazole, fluoxetine, fluvoxamine, ketoconazole The US Food and Drug Administration has issued a warning that omeprazole (Prilosec) reduces the antiplatelet activity of clopidogrel (Plavix) by about 50%
Plavix is used to lower your risk of having a stroke, blood clot, or serious heart problem after you've had a heart attack, severe chest pain ( angina ), or circulation
In 2009, the FDA issued a warning that omeprazole–a proton pump inhibitor (PPI)–reduces the antithrombotic effect of clopidogrel by almost half when taken
22 Pantoprazole may
3 Proton pump inhibitors are inhibitors of CYP2C19 with varying degrees of potency
Omeprazole is a proton pump inhibitor (PPI)
It reduces the chance that a harmful blood clot will form by preventing platelets from clumping together in the blood
Drug class or drug name: Drug examples: Interaction result with Plavix: CYP2C19 inhibitors • omeprazole (Prilosec) • esomeprazole (Nexium) can make Plavix less effective than usual Clopidogrel treatment did not the alter platelet function of subject #3, indicating a non-responder status
Background Omeprazole is a common proton pump inhibitor that interferes with the hepatic activation of clopidogrel and potentially reduces its platelet-inhibitory effect
In humans, the concurrent use of these two drugs can reduce the anti-platelet efficacy of clopidogrel
Biological Plausibility of the Clopidogrel–PPI Interaction? PPIs may reduce the availability of the biologically active metabolite of clopidogrel by competitively inhibiting cytochrome P450 2C19 (CYP2C19), one of the isozymes responsible for the step-wise hepatic oxidation and subsequent hydroxylation of the thienopyridine prodrug
Alternative options to PPIs include H2-blockers, like Pepcid, and But the FDA warned in November of 2009 that taking Prilosec, Nexium or the generic drug omeprazole could reduce the efficacy of Plavix by 50%
Omeprazole has long been one of the most widely used PPIs
+ Tránh kê đơn omeprazole và esoprazole Common omeprazole side effects may include: cold symptoms such as stuffy nose, sneezing, sore throat (especially in children); fever (especially in children); stomach pain, gas; nausea, vomiting, diarrhea; or
Your doctor will advise you if you need to take aspirin as well
In clinical studies, omeprazole was shown to reduce significantly the antiplatelet activity of Plavix when given concomitantly or 12 hours apart