Indications
In a randomized, double-blind trial of cyclosporine by Young and colleagues, patients with severe TBI (Glasgow Coma Scale [GCS] 4–8) were assigned to one of four dose cohorts (placebo n=2, cyclosporine n=8 for each cohort): 0
In 1971, its immunosuppressive properties were identified in a screening test ( 1 , 4 ) and in 1976, its chemical structure was determined ( 3 , 5 )
1920130516 We investigated the pharmacokinetics of cyclosporin A (CsA) blood levels and drug toxicity in a chronic rat study in which long
Animals were maintained on oral cyclosporine (210 mg/L) administered in the drinking water from 1 day prior to transplantation until the animals were sacrificed
Thus, 45 non-transplanted Wistar rats were treated for 8 weeks with vehicle or 5 or 15 mg/kg CsA (n = 15/group) by gavage administration to evaluate the specific
Abstract A number of mechanisms participate in the hepatic injury that occurs during and following liver transplantation
The present study aimed to explore the therapeutic effects of cyclosporin A (CsA) on spinal cord injury (SCI) in rats with hyperglycemia and to identify a novel potential method to
Serum CYA levels were kept in the range that is often encountered in clinical immunotherapy in humans
The Royal College of Surgeons (RCS) rat is an established model of retinal degeneration, which has been mainly used for studying photoreceptor rescue with treatment at the age of 3–4 weeks
Transplanted fetal RPE was rejected within 1 month into the rabbit eye but survived at 3 Cyclosporine half-life varies between 6-24 hours
Initial dose: 1
Methods: Male Sprague-Dawley rats received 30 min of warm ischaemia followed by a period of reperfusion of 6 h
The dystrophic RCS rat undergoes progressive photoreceptor degeneration due to a primary defect in retinal pigment epithelial (RPE) cells
However, it is associated with many side-effects on different tissues and body organs including the periodontal tissues
Background: Immune thrombocytopenia (ITP) and autoimmune hemolytic anemia (AIHA) show good responses to frontline steroids
(25 mg/kg) for 28 days
Abstract— This study was designed to investigate the effects of chronic treatment with cyclosporin A (CSA) on the endogenous synthesis of prostanoids (PGs) and
There was a 176% increase in glomerular ZO-1 expression in PAN rats (n=6) compared to Control rats (n=6)
Cyclosporine A (CsA) is an immunomodulator drug that can improve eye allergy and reduce the need for steroids; however, topical preparation of CsA is difficult because of the lipophilic nature of the drug