Phenytoin is used to prevent and control seizures (also called an anticonvulsant or antiepileptic drug)
The story of how scientists defined the mechanism of action of phenytoin during its 80 years history is, therefore, relevant, because it adds a new context to the
Alternatives
Dilantin (phenytoin) is an anti-epileptic drug, also called an anticonvulsant, used to control seizures
It has a role as an anticonvulsant, a teratogenic agent, a drug allergen and a sodium channel blocker
Phenytoin cream might become a new treatment modality of the treatment of neuropathic
, diazepam, lorazepam, midazolam) are considered drugs of choice for initial treatment of status epilepticus; IV phenytoin (or fosphenytoin) may be used as a second-line agent if
It is therefore used to control tonic-clonic (grand mal Before taking phenytoin, tell your doctor or pharmacist if you are allergic to it; or to other anti-seizure medications (such as carbamazepine, ethosuximide, ethotoin, fosphenytoin, oxcarbazepine Fosphenytoin is a medication used to manage seizures (treatment of generalized tonic-clonic status epilepticus, focal [partial] onset seizures, or generalized onset seizures, and for the prevention and treatment of seizures occurring during neurosurgery)
[] Phenytoin's inhibitory effect is dependent on the voltage and frequency of neural cell firing by selectively blocking the neurons that are firing at high frequency
At high concentrations Phenytoin 1
It exerts this effect by preventing the excessive accumulation of intracellular sodium during tetanic stimulation by either reducing the passive influx of sodium or increasing the Although phenytoin has been identified as an anticonvulsant drug 80 years ago, its mechanism of action in epilepsy and in the many other indications is still uncertain
unusual bruising or bleeding
This activity outlines the indications, mechanisms of
Its exact mechanism of action has not been established but it is expected to stabilise neuronal membranes and reduce seizure activity by increasing efflux or decreasing influx of Na ions across cell membranes in the motor cortex during generation of nerve impulses
slurred speech
Phenytoin 5% cream reduced the allodynia and other pain symptoms to 3 on the NRS with an onset of action of 5 minutes with the duration of effect of 8 hours
Be alert for phenytoin hypersensitivity syndrome (fever, skin rash, lymphadenopathy)
Phenytoin is available under the following different brand names: Dilantin, Dilantin 125, and Phenytek
Posttetanic potentiation at synaptic
[4] Mechanism of Action