Cyclosporine is used to prevent organ rejection after a kidney, heart, or liver transplant
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Current Status of Adverse Event Profile of Cyclosporine in Kidney, Stem Cell, and Heart Transplantations Using the Japanese Pharmacovigilance
The most notable adverse effects associated with oral cyclosporine are gastrointestinal, including diarrhea, vomiting/nausea, and anorexia; Table 2 lists side effects seen in dogs
When a patient receives an organ transplant, the body's
Kidney transplant: The typical starting dose ranges from 6 mg/kg to 12 mg/kg by mouth, split into two equal doses daily
Cyclosporin A (CsA), a fungal metabolite from Tolypocladium inflatum, was the first CNI approved by the US Food and Drug Administration for kidney transplantation in 1983
Cyclosporine is used in combination with other medicines (eg, azathioprine, steroid medicines) to prevent the body from rejecting a transplanted organ (eg, kidney, liver, or heart)
Cyclosporine was discovered in 1972 and first used in humans in 1978 as an immunosuppressant drug used to prevent the body from rejecting a transplanted organ
Monitoring whole blood peak cyclosporine concentration during therapy, particularly in individuals coadministered cytochrome P450 (CYP) 3A4 substrates, inhibitors, or inducers Adjusting dose to optimize immunosuppression while minimizing toxicity Evaluating patient compliance
Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication
31 have shown that secondary metabolites of cyclosporine A may be associated with toxicity in kidney transplant patients
high blood pressure, kidney disease, or In 1978-79 the first successful results of the use of cyclosporine in kidney were reported
cyclosporine will increase the level or effect of aliskiren by P-glycoprotein (MDR1) efflux transporter
4; 95% CI, 16
It is routinely monitored by predosage blood trough level (C0) or two hours post dose level (C2)
Materials and methods: In 50 kidney transplant recipients, serum cyclosporine level, fasting blood glucose, and serum creatinine were measured 7 times during first 6 months after transplantation