Fosphenytoin is doses in phenytoin equivalents (PE) to prevent confusion with dosing
Adjust dose as needed; most adults can be maintained on 300 to 400 mg/day in divided doses
If the rash was to reoccur manufacturer’s advice is that further phenytoin therapy is contraindicated
fever, sore throat, rash, mouth ulcers, or easy bruising, or facial swelling
We have previously carried out testing on different formulation with our filters and can perform similar testing as required
Fig 3
The equation below gives an albumin corrected total phenytoin concentration, which can be compared with the target concentration range (10–20mg/L)
This chart is an update to the 2012 article published in Hospital Pharmacy on injectable drugs to be used with a filter
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Phenytoin can be administered as an intravenous infusion, or it can be given orally, and there is little difference in the dosing
5 mg fosphenytoin sodium, USP (hereafter referred to as fosphenytoin) equivalent to 1 mg phenytoin sodium and is referred to as 1 mg phenytoin equivalents (PE)
An additional safety factor is the absence of propylene glycol in the fosphenytoin formulation
Filters administering parenteral nutrition 1 / 36
When, in the judgment of the clinician, the need for dosage reduction, discontinuation, or substitution of alternative antiepileptic medication The rate of intravenous phenytoin administration should not exceed 50 mg/minute in adults and 1 to 3 mg/kg/minute (or 50 mg/minute, whichever is slower) in pediatric patients because of the risk of severe hypotension and cardiac arrhythmias
There is limited evidence that fosphenytoin may be a more appropriate choice in selective populations
The maximum rate of administration is 50 mg/min in adults and 0