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If you’re living with lupus and are taking methotrexate (Rheumatrex, Trexall) to help treat joint inflammation and pain, you may develop heartburn and acid reflux
Omeprazole / therapeutic use
Omeprazole (Oral Route) Omeprazole is used to treat certain conditions where there is too much acid in the stomach
Take omeprazole capsules or delayed-release capsules before a meal, preferably in the morning
Manufacturer advises use with caution or avoid
If you take omeprazole
This includes prescription and non-prescription medicines as well as birth control pills, vitamins, and herbal supplements
It is created by eHealthMe based on reports from the
Can be taken once daily unless the dosage is more than 80mg/day, then the dosage should be split
Evidence: Study
Ritonavir, a strong cytochrome P450 (CYP) 3A4 inhibitor and a P-glycoprotein (P-gp) inhibitor, is coadministered with nirmatrelvir to increase the blood concentration of nirmatrelvir, thereby making it effective against SARS-CoV-2
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In particular, bowel perforations are more common in people who take steroids
Wash your hands after touching the tablets to remove any traces of methotrexate powder
PPI drugs include: Prilosec ; Nexium (esomeprazole) Protonix (pantoprazole) Aciphex (rabeprazole) Prevacid (lansoprazole) One such study stated the
You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications
It can also interact with certain blood pressure medications, lithium, and methotrexate
Non-PPI options include histamine blockers, antacids, probiotics and lifestyle changes
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances
Even when taken daily, PPIs like omeprazole take up to 4 days to reach their maximal effect
Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan
Prescription omeprazole is often taken for 4 to 8 weeks, depending on what you’re treating
Hi barbieg , i just posted yesterday on lupus site about my son taking omeprazole with methotrexate, the consensus was you shouldn’t take it