Trazodone is the first antidepressant with a dual mechanism of action involving inhibition of the serotonin transporter (SERT) and serotonin type 2 (5-HT 2) receptor antagonism (both the 5-HT 2A and 5-HT 2C receptors) []
OBJECTIVE: While trazodone is approved for the treatment of depression, the off-label use of this medication for insomnia has surpassed its usage as an antidepressant
The Food and Drug Administration (FDA) approved these atypical antidepressants to treat depression: Bupropion (Wellbutrin SR, Wellbutrin XL, others) Mirtazapine (Remeron) Nefazodone
Trazodone is an antidepressant, but it does not cure depression or anxiety
There are several TCAs available, but four commonly used options are: SSRIs, SNRIs, and bupropion are some of the most commonly prescribed types of antidepressants
Trazodone hydrochloride tablets should be taken shortly after a meal or light snack ( 2 )
It has been used to help with anxiety as well, but most commonly is used off-label to take advantage of its tendency to cause sedation and help with insomnia
It is classified as a serotonin antagonist and reuptake inhibitor (SARI), it is not an SSRI, and it works by increasing the levels of serotonin in the brain
Trazodone comes as tablets, capsules Trazodone (Oral Route) Drug information provided by: Merative, Micromedex
Experts aren’t sure exactly how trazodone works but suggest it improves the symptoms of depression by inhibiting the uptake of serotonin by nerves in the brain
Desyrel (Trazodone Hydrochloride) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources
Case reports also suggest that the serotonin-norepinephrine reuptake
Signs and symptoms such as nausea, weight gain or sleep problems can be common initially
SSRIs work by blocking the reuptake of serotonin, while SNRIs block the uptake of both serotonin and norepinephrine