The therapeutic range for valproic acid is 50-100 mcg/mL
At a normal albumin concentration and low total serum concentration (20–60 mcg/mL), the unbound fraction of VPA is approximately 10% of the total serum
The generally accepted therapeutic range for total valproic acid steady-state concentrations is 50–100 μg/mL, although some clinicians suggest drug concentrations as high as 175
acid (VPA) often is used to treat mania in bipolar disorder, and it has a therapeutic range of 50 to 125 μg/mL of total serum concentration
Further workup revealed nephrotic syn-drome with an albumin level of 2
The corresponding range of free valproic acid concentration for clinical reference is 5 to 25 mcg/mL
Chart depicting the individual subject's serum valproic acid levels at 12 and 24 h It is observed that measuring serum VPA levels at 24 h is recommended and provides a
The effect of hypoalbuminemia on free fraction has been quantified and serves as the basis of an equation used to "correct" measured total valproic acid concentrations
Who can and cannot take valproic acid
If dosages are adjusted on the basis of total valproic acid levels, patients who are hypoalbuminemic can be overdosed, leading to clinically signifi-cant neurologic symptoms or toxicity (10, 15)
Background: Valproic acid, a GABAergic drug, has been shown to be effective for migraine prophylaxis
Toxic effects of corrosive acids and acid -like substances
Valproic acid levels in breastmilk are low and infant serum levels range from undetectable to low
Valproate has been shown to be effective in several forms of seizures
Profound as well as partial biotinidase deficiency causes dermatologic manifestations similar these
The risk of developing liver damage is greater in children who are younger than 2 years of age and are also taking more than one medication to prevent seizures, have certain inherited diseases that may prevent the body from
ORDERING INFORMATION: Geisinger Epic Procedure Code: LAB3230 Geisinger Epic ID: 14240
Stat/Line draws: 3 mL green/yellow-top (plasma separator) tube
Modify Therapy/Monitor Closely
Background: Therapeutic drug monitoring (TDM) is recommended during valproic acid (VPA) use, and total serum concentration has been widely adopted