A novel brain targeting l-ascorbic acid derivatives with "lock-in" function were designed and synthesized as prodrugs to achieve the effective delivery of ibuprofen to brain by glucose transporter 1 (GLUT1) and the Na(+)-dependent vitamin C transporter SVCT2
-induced neurotoxicity
Slices with maintained ascorbate levels also have better histological characteristics than ascorbate-depleted tissue
Vitamin C concentrations in the brain exceed those in blood by 10-fold
Under brain activity, ascorbic acid is released from glial reservoirs to the synaptic cleft, where it is taken up by neurons
Vitamin C is a powerful antioxidant that can strengthen your body’s Ascorbic acid (AA, vitamin C) is an essential nutrient that functions as an important reducing agent, free radical scavenger, and co-factor in numerous biosynthetic reactions [13,14,15]
Figure 1 shows ascorbate uptake and metabolism in
The effect of ascorbic acid (1 g/kg ip) on the half-life of amphetamine (10 mg/kg) in rat brain using 3H-amphetamine and on amphetamine-induced stereotyped behaviour was investigated
When the two are combined, it creates a clear liquid form called leukoMethylene Blue with increased In contrast, the oxidized form of vitamin C, dehydroascorbic acid (oxidized ascorbic acid), readily entered the brain and was retained in the brain tissue in the form of ascorbic acid
Rats were injected with lead ac