Drug class: Calcium-Channel Blocking Agents, Miscellaneous - Calcium-Channel Blocking Agents, Nondihydropyridine - Nondihydropyridine Calcium-Channel Blocking Agents -
Includes common brand names, drug descriptions, warnings, side effects and dosing information
Chemically, diltiazem hydrochloride is 1,5
It may help to increase your ability to exercise and decrease how often you may get angina attacks
Your doctor may adjust your dose as needed
Generic name: diltiazem [ dil-TYE-a-zem ] Brand names: Cardizem, Cardizem CD, Cardizem LA Drug classes: Calcium channel blocking agents, Group IV
A
25 mg/kg based on actual body weight (average dose: 20 mg) by direct IV injection over 2 minutes
8 fold
Evaluate for loss of therapeutic effect if medication must be coadministered
Diltiazem hydrochloride inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility
Diltiazem hydrochloride injection is a calcium ion influx inhibitor (calcium entry blocker or calcium ion antagonist)
Side Effects
A study that compared patients with normal hepatic function to patients with cirrhosis found an increase in half-life and a 69% (Classification) Cardizem/diltiazem
Minimum therapeutic plasma levels of diltiazem hydrochloride appear to be in the range of 50 ng/mL to 200 ng/mL
The plasma elimination half-life following single or multiple drug administration is approximately 3
Diltiazem is used alone or together with other medicines to treat angina (severe chest pain) or hypertension (high blood pressure)
PO (Adults): 30–120 mg 3–4 times daily or 180–240 mg once daily as CD or XR capsules or LA tablets (up to 360 mg/day); Concurrent simvastatin therapy: Diltiazem dose should not exceed 240 mg/day and simvastatin dose should not exceed 10 mg/day
Feeling dizzy, tired, or weak
Diltiazem hydrochloride is a calcium ion cellular influx inhibitor (slow channel blocker or calcium antagonist)
Minimum therapeutic plasma levels of diltiazem appear to be in the range of 50 to 200 ng/mL
Minimum therapeutic plasma levels of diltiazem hydrochloride appear to be in the range of 50 - 200 ng/mL
Substances acting primarily via the inhibition of calcium entry into the cell have been divided into four distinct classes
25 mg/kg (actual body weight) over 2 minutes (average dose: 20 mg); if rate control is insufficient after 15 minutes, a repeat bolus dose of 0