Clonidine has a vast array of uses including anxiety, ADHD, hypertension, withdrawal (opitates, alcohol and smoking), migraines, menopausal flushing, diarrhoea and finally pain
Clonidine is a central alpha-agonist that is used as an antihypertensive agent
2,3 However Side effects Interactions What is clonidine? Clonidine lowers blood pressure by decreasing the levels of certain chemicals in your blood
For oral dosage form (tablets): Adults—0
, 13 to 51 patients), were not specific to hypertensive urgency, and were published many years ago (1988-1990)
Guanfacine is related closely to guanabenz and has more selective alpha 2 agonist activity than does clonidine
However, in cases of overdose or misuse, clonidine toxicity can occur, leading to potentially severe symptoms
3 mg specifically), the response to clonidine is generally not predictable on clinical grounds
1 Clonidine's alpha-agonist properties decrease stimulation of receptors in the heart, vessels, and kidneys resulting in decreased vascular resistance, heart rate, and cardiac contractility while increase vasodilation
Calcium channel blockers (CCBs) are among the most commonly used cardiovascular drugs in the adult population
It is a centrally acting alpha-2 receptor agonist
Clonidine, an alpha-2 adrenergic agonist, is a biochemical derivative of imidazoline that was initially introduced as a topical nasal decongestant over 40 years ago [ 1 ]
We conducted a thorough literature Clonidine is a biochemical derivative of imidazoline and has agonist activity at alpha-2 adrenergic receptors and imidazoline I2 receptors
1 mg/kg, there was an equivalent hyperglycemic response in fed rats whether clonidine was administered orally, i
Overdoses of immediate-release CCBs are characterized by rapid progression to hypotension, bradydysrhythmia, and cardiac arrest
α2-agonism leads to activation of inhibitory neurons in the nucleus tractus solitarius causing decreased norepinephrine release, precipitating decreased sympathetic outflow
1 mg, 0
Clonidine overdose in childhood: implications of increased prescribing
This is why propranolol and acebutolol can cause seizures, QRS prolongation, and ventricular tachycardia
Context: There are limited reports of adult clonidine overdose
It seems that in CCBs poisoning, insulin release is significantly low, leading to a sudden and significant fall in insulin concentration in the blood and tissues as well
In patients with renal disease Context: There are limited reports of adult clonidine overdose
The somnolence is frequently treated with endotracheal intubation (ETI), a procedure with significant morbidity
This webpage provides a comprehensive overview of the clinical features, diagnosis, and management of beta blocker poisoning, including the use of antidotes such as glucagon, calcium, and dialysis
Pediatric postoperative pain
In recent years it has gained popularity in pediatric patients for the treatment of attention-deficit hyperactivity disorder (ADHD Background: Tizanidine is a centrally acting muscle relaxant with a novel mechanism of action and structurally related to clonidine
Pioglitazone and Glimepiride (Duetact®) - the glimepiride component of this drug gives it the possibility of causing hypoglycemia alone or in combination with other diabetes medicines
Hyperglycemia, or high blood sugar, is a serious condition that can lead to diabetes and other health problems
Compared to clonidine, guanfacine is a more selective agonist for alpha-2A receptors (compared to alpha-1, alpha-2B, alpha-2C, and imidazoline receptors)
10, 11 As a result of this use in the pediatric population, there is widespread availability of clonidine to children, and frequent unintentional overdoses continue to occur
The median dose ingested was 13 mcg/kg (interquartile range: 7-38 mcg/kg), which varied across ages
It is also used to treat inflammatory bowel disease in dogs and cats and behavioral disorders in dogs
What is clonidine and what does it treat? Clonidine is a non-stimulant prescription medication that is used to treat attention-deficit hyperactivity disorder (ADHD)
These results suggest that clonidine-induced hyperglycemia is associated with not only the suppression of insulin release but also the stimulation of glucagon release
Harris, MDb,T aEmergency Medicine Department, Saint John's Hospital, Maplewood, MN 55109-1169, USA bEmergency Medicine Department, Regions Hospital, 640 Jackson Street, St
Contact information for poison control centers around the world is available at the WHO website and Objectives: Describe the basic pathophysiology/toxicokinetics of clonidine toxicity
Clonidine has a vast array of uses including anxiety, ADHD, hypertension, withdrawal (opitates, alcohol and smoking), migraines, menopausal
Clonidine is an antihypertensive drug that lowers blood pressure and heart rate by relaxing the arteries and increasing the blood supply to the heart; it has the following FDA-approved indications:
Side effects Interactions What is clonidine? Clonidine lowers blood pressure by decreasing the levels of certain chemicals in your blood
It is a disease of exclusion and is defined as dysregulation in the autonomic function system and manifests as tachycardia and tachypnea
Ingestion of more than the recommended amount can cause an overdose
Clonidine overdose most commonly presents with hypotension, bradycardia, and altered mental status
2, 3 However, here we Clonidine also has been used to alleviate opioid and nicotine withdrawal symptoms
Methods: This was a retrospective review of a prospective cohort of poisoned patients who took clonidine overdoses (>200 μg)
2 mg, or 0
Patients with acute cocaine toxicity presenting to the emergency department (ED) may require urgent treatment for tachycardia, dysrhythmia, hypertension, and coronary vasospasm, leading to pathological sequelae such as acute coronary syndrome, stroke, and death
Unintentional pediatric exposures to central alpha-2 agonists reported to the National Poison Data System
1, 9 Despite this, there are limited data on outcomes of
As a result of this use in the pediatric population, there is widespread availability of clonidine, and unintentional overdoses occur
Clonidine alone n¼41 (78
15 mg over 10 min) on several endocrine and metabolic variables have been evaluated in 12 hypertensive patients and 12 normotensive controls
Learn about the causes, symptoms, diagnosis and treatment of hyperglycemia from Cleveland Clinic, a leading health organization
2-mg clonidine hydrochloride tablet and developed coma, respiratory depression, and hypotension
• The dose usually ranges from 0
It is used orally (by mouth), by injection, or as a
Authors A Mimouni-Bloch, M Mimouni
Methods: Retrospective review of all ingestions involving tizanidine reported to a poison control center from January 2000 through February 2003
Clonidine has also been used to alleviate opioid and nicotine withdrawal symptoms
For oral dosage form (tablets): Adults—0
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