The free base contains 39% iodine by weight (fig 1), and chronic treatment is associated with 40-fold increases in plasma and
Amiodarone toxicity can therefore occur well after drug withdrawal [ 4 ]
Amiodarone (AMD) treatment is associated with a number of significant adverse effects including thyroid dysfunction
Amiodarone is a widely prescribed benzofuranic antiarrhythmic drug rich in iodine that may affect both thyroid function tests and thyroid function itself, inducing
Treatment with amiodarone is associated with changes in thyroid function tests, but also with thyroid dysfunction (amiodarone-induced hypothyroidism, AIH, and amiodarone
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Amiodarone treatment results in a large iodine load and affects thyroid status by decreasing peripheral deiodination of thyroxine (T 4) to tri-iodothyronine (T 3 ), leading to an
Abstract
Amiodarone treatment results in a large iodine load and affects thyroid status by decreasing peripheral deiodination of thyroxine (T 4) to tri-iodothyronine (T 3 ), leading to an
The Mechanism for Amiodarone-Induced Hyperthyroidism and Clinical Implications
The incidence of AIT varies greatly
4 mU/liter or higher was reached by initial therapy in all patients of groups A and C but required the addition of prednisone in four
5 (range: 14
A case-control analysis was performed, with patients matched for duration of amiodarone therapy
The onset time of amiodarone-induced thyrotoxicosis (AIT) depends on AIT type Eur J Endocrinol
Treatment with amiodarone is associated with changes in thyroid function tests, but also with thyroid dysfunction (amiodarone-induced hypothyroidism, AIH, and amiodarone-induced thyrotoxicosis, AIT)
Amiodarone has a half-life of 100 days, with a large volume of distribution, which further enhances its toxicity and predisposes to drug withdrawal
Introduction Amiodarone-induced thyrotoxicosis is associated with high morbidity and mortality rates
Recommendations include the following [ 17] : Patients with amiodarone-induced thyrotoxicosis (AIT) should be considered at risk of an emergency treatment at any
Because the time‐to‐onset of
Men are at increased risk of amiodarone-associated thyrotoxicosis in the UK
In the absence of autoimmunity, the withdrawal of amiodarone can be considered in subclinical cases
However, amiodarone is associated with a number of side effects, including thyroid dysfunction (both hypo- and hyperthyroidism), which is due to
Dimens Crit Care Nurs
the risk of thyroid dysfunction increased gradually with the duration of amiodarone intake in non-ACHD patients (HR 3
Amiodarone-induced thyrotoxicosis (AIT) type 1, a form of iodine-induced hyperthyroidism, typically develops in patients with underlying Graves' disease or nodular goiter ()