It may help you stay asleep longer and reduce the number of times you awaken during the night
It is a white crystalline solid readily soluble in water, lower alcohols and chloroform
Doxazosin (high risk of orthostatic hypotension; not recommended as routine treatment for hypertension; alternative agents have superior risk/benefit profile) Doxepin (>6mg/d)
hypotension; safety profile of low-dose doxepin (Amitriptyline comparable to that of placeboAmoxapine Clomipramine Desipramine Doxepin >6 mg/d Imipramine
Amitriptyline, amoxapine, clomipramine, desipramine, doxepin (> 6 mg/d) imipramine, nortriptyline, paroxetine, protriptyline, trimipramine Antipsychotics – 1st (conventional) &
1mg/d) (high risk of adverse CNS effects; may cause bradycardia and orthostatic hypotension; not rec-ommended as routine treatment for hypertension)
Low dose doxepin (3 mg and 6 mg) is FDA approved for the treatment of sleep maintenance
12 attempted to preserve the spirit and intent of the original Beers Criteria by providing an explicit 13 list of PIMs that are best avoided by older adults in most circumstances or under specific 14
This information does not contain all possible interactions or adverse effects
Constipation, diarrhea, stomach pain, upset stomach, throwing up, or feeling less hungry
For the 2019 update, an interdisciplinary expert panel reviewed the evidence published since the last update (2015) to determine if new criteria The AGS Beers Criteria® is an explicit list of PIMs that are typically best avoided by older adults in most circumstances or under specific situations, such as in certain diseases or conditions
It is used as a cream for itchiness due to atopic dermatitis or lichen
urinary retention
› Paroxetine (SSRI): Highly anticholinergic › Antipsychotics, first (conventional) and second (atypical) generation DOXEPIN (anticholinergic effects and sedation) Ergot mesyloids (uncertain efficacy at doses studied) Estrogens only, oral forms (carcinogenicity and lack of cardioprotective effect in older women) Ethacrynic acid (may cause hypertension, fluid/electrolyte imbalances; use safer alternatives) Ferrous sulfate (doses over 325mg/day are Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs
Bottom Line
The five lists included describe particular medications with evidence suggesting they should be avoided, used in caution, or dosed
Side Effects
Doxepin >6 mg/day (H) Fluoxetine (H) Perphenazine-amitriptyline (H) Antihypertensive