In individuals Amiodarone-induced hypothyroidism (AIH) is due to the inhibition of iodide oxidation because of excess intrathyroidal iodine, which is known as the Wolff-Chaikoff
Failure to escape from the Wolff-Chaikoff effect may occur in patients with an apparently normal thyroid gland thus causing amiodarone-induced hypothyroidism (AIH)
The pathogenesis of iodine-induced AIH is related to a failure to escape from the acute Wolff-Chaikoff effect due to defects in thyroid hormonogenesis, and, in patients with
Untoward effects associated with amiodarone use, including effects on the pulmonary, gastrointestinal, ophthalmologic, neurologic, dermatologic and thyroid
Escape from the acute Wolff–Chaikoff effect occurs because of a decrease in the expression of the Cohen-Lehman J, Dahl P, Danzi S, Klein I
Iodine may The most common side effect of amiodarone use is thyroid dysfunction, (TPO), a protective reflex known as the Wolff-Chaikoff effect
6 Although this is apparent within the first 2 weeks of treatment, further exposure
The mechanism for this acute Wolff-Chaikoff effect is partially explained by generation of substances such as iodolactones, iodoaldehydes, and/or iodolipids, that inhibit thyroid peroxidase (TPO) and a 76-year-old man with prior amiodarone use who developed new-onset atrial fibrillation after eight iodinated CT scans over 10 months
(1999), the inhibitory effect of amiodarone occurs at a lower iodide concentration than that for sodium iodide, and the effect of amiodarone is irreversible, indicating possible persistence of the Wolff–Chaikoff effect due to a persistently high intracellular iodide level
Endocrinol
In patients with multinodular goiter or latent Graves’ disease hyperthyroidism may occur
Patients treated with amiodarone may manifest altered thyroid hormone profile without thyroid dysfunction, or they may present with clinically significant amiodarone-induced hypothyroidism or amiodarone-induced thyrotoxicosis
Pathology
This escape from the protective Wolff-Chaikoff effect is called the Jod-Basedow phenomenon