This is not a complete list of all corrected QT interval (QTc)-prolonging drugs and does not include drugs with either a
Metoclopramide administration increases the QT/RR slope and QT variance
Metoclopramide is generally safe to give when the QTc interval for men is less than 450 milliseconds per beat, and for women, less than 460 milliseconds per beat
Of these, ondansetron and granisetron are the most frequently encountered
This case report highlights the “perfect storm” of electrolyte disturbance (potassium, magnesium) and medication effects (fluoxetine, ondansetron, and
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They are just one of a
Males >440-450 ms
He is also a Clinical Adjunct Associate Professor at Monash University
In addition, metoclopramide has been mechanistically shown to change QT dynamics , as well as showing a signal in epidemiological research
Normal QT interval – The normal range for the rate-corrected QT interval (QTc) is similar in males and females from birth until the start of adolescence, while after puberty and in adults, females have slightly longer QT intervals than males
2 A number of drugs have been implicated in prolongation of the QT interval, including
1 ECG readings showed QTc intervals of 413-457 msec with a change from baseline of 12-42 msec
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8]), where in both cases, the proposed mechanism was QT prolongation
lip smacking or puckering
Antiadrenergic effects (blockage of the alpha1-adrenergic receptor) can lead to
Accurate calculation of baseline QT interval, careful review of a patient’s medication list, and obtaining a thorough family history are paramount to avoiding iatrogenic QT prolongation
*Secondary variables: Changes in QTc interval at different time intervals in each Metoclopramide can cause extrapyramidal effects, including irreversible tardive dyskinesia, although this is rare (incidence of less than 1%)
32 ondansetron, 31 and prochlorperazine
Though studies have found conflicting results, domperidone has been implicated in causing QT prolongation, ventricular arrhythmias and sudden cardiac death
Although a prolonged QTc is usually defined as a QTc exceeding 450-480 msec, the risk of torsades de pointes (TdP) begins to become concerning when the QTc is more than 500 msec, 15-20% longer than baseline, or if the QTc has increased by more than