The structures of pioglitazone and its oxidovanadium(IV) complex were analyzed by using physicochemical and spectroscopic techniques
Fold change in the adipose tissue mRNA expression of genes involved in
To the best of our knowledge, this is the first hydride and transition-metal free protocol for the synthesis of Pioglitazone, highlighting its potential utility as a greener
Pioglitazone inhibits pyruvate-driven ATP synthesis in isolated mitochondria
These data indicate that pioglitazone therapy restores insulin sensitivity, in part, by a coordinated upregulation of genes involved in mitochondrial OXPHOS and
This article examines published analytical methods reported so far the method provided by this article has the following disadvantages: 1
Various analogues of a new antidiabetic agent, pioglitazone (AD-4833, U-72107), were synthesized in order to study in more detail the structure-activity relationships of this class of drug
A new library of hybrid compounds that combine the functional parts of glibenclamide and pioglitazone was designed and developed
Context: In this study, we aimed to identify the determinants of mitochondrial dysfunction in skeletal muscle (SKLM) of subjects with type 2 diabetes (T2DM), and to evaluate the effect of pioglitazone (PIO) on SKLM mitochondrial proteome
The conditions were improved to 1 atm at 296 K, which results in a quantitative product with a smaller
On the other hand, pioglitazone decreased blood glucose by 29% and 52% at 60 and 180 min, respectively
its main mechanism of action is to increase the secretion of insulin by the pancreas [5]
Exploiting the advantages of this approach, we have proposed a good number of synthesis schemes for a p tent anti-diabetic drug ‘Pioglitazone’
Administration of pioglitazone alone did not affect pancreatic DNA synthesis
in 2008, with sales exceeding $2
Background Pioglitazone, a synthetic peroxisome proliferator activated receptor (PPAR-γ) ligand, is known as an antidiabetic drug included in the thiazolidinediones (TZDs) class
Activation of nuclear PPARgamma receptors influences the production of a number of gene products involved in glucose and lipid metabolism
ACC is an important fatty acid synthetase and an enzyme that controls the rate of synthesis of malonyl COA