Pioglitazone synthesis

The first described synthesis of pioglitazone started with condensation of 1-fluoro-4-nitrobenzene ( 26. Pioglitazone is indicated in the treatment of type-2 diabetes mellitus: as monotherapy: in patients (particularly overweight patients) inadequately controlled by diet and exercise for whom metformin is inappropriate because of contraindications or intolerance; as dual oral therapy in combination with: metformin, in patients (particularly overweight patients) with insufficient glycaemic control Thiazolidinediones, such as pioglitazone, are synthetic ligands for peroxisome proliferator-activated receptors (PPARs)

2024-03-29
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  2. Int J Mol Sci2022 Feb 25;23 (5):2522
  3. [3] It is taken by mouth
  4. Abstract
  5. It is used for the treatment of diabetes mellitus type 2
  6. 2007
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  8. 91 ± 5