They include medications that end with the suffix “-dipine”, such as nifedipine, nicardipine, nimodipine, and amlodipine, to name a few
Amlodipine is an oral dihydropyridine calcium channel blocker
Cardiac outflow obstruction (for example significant aortic stenosis or obstructive hypertrophic cardiomyopathy) —
Calcium channel blockers should generally be avoided in patients with heart failure with reduced ejection fraction (HFrEF) since they provide no functional or
Application of amlodipine at a
VA class: CV200
Amlodipine works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium
Amlodipine's maximum dose is 10 mg daily
6 X 10(-6) M to isolated guinea-pig papillary muscle for 120 minutes produced a 50% reduction in tension development compared with a concentration of 3
They specifically stated that “a nondihydropyridine and dihydropyridine calcium antagonist have additive and even synergistic blood pressure–reducing capabilities
Dihydropyridine CCBs (such as amlodipine and felodipine) are contraindicated in people: With uncontrolled heart failure
CCBs are classified broadly as either dihydropyridine or non‐dihydropyridine types
Hypertension Research - Dihydropyridine calcium channel blockers and renal disease
[3] Amlodipine lần đầu tiên được cấp bằng sáng chế vào năm 1986
Indications and dose For amlodipine Angina, Hypertension for amlodipine By mouth
Methods This review paper will focus on amlodipine, a dihydropyridine calcium channel blockers, which has been widely used for 2 decades
Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle
An 18-week, prospective, randomized, double-blind, multicentre study of amlodipine/ramipril combination versus amlodipine monotherapy in the treatment of hypertension: The assessment of combination therapy
Nifedipine XL is designed to provide BP control at a constant rate over 24 hours and has a shorter half‐life than amlodipine (≥44 hours), 13 but in most patients it provides adequate BP control over a 24‐hour period, provided the dose is adjusted appropriately
beta blockers, antihypertensives) to produce excessive hypotension or negative inotropic effects