Simvastatin acts primarily in the liver, where decreased hepatic cholesterol concentrations stimulate the upregulation of hepatic low density lipoprotein (LDL) receptors which increases hepatic uptake of LDL
" Simvastatin is used to lower blood levels of "bad" cholesterol(low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a
Simvastatin is used together with diet, weight-loss, and exercise to
SIMVASTATIN (SIM va sta tin) treats high cholesterol and reduces the risk of heart
Statins include atorvastatin (Lipitor), fluvastatin (Lescol XL), lovastatin
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Simvastatin (Zocor, FloLipid) and atorvastatin (Lipitor) are both statin
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Aug 17, 2023 · What Is Zocor? Zocor (simvastatin) is a statin that lowers lipids and cholesterol levels used in conjunction with lifestyle changes such as a low-fat, low cholesterol diet, and exercise to reduce the chances of cardiovascular disease and ischemic strokes in patients with elevated lipids and cholesterol
Sep 14, 2023 · Simvastatin (Zocor, FloLipid) is a prescription medication that lowers cholesterol
2 nM。Simvastatin 可减少胆固醇的合成,降低血液中的胆固醇水平。Simvastatin 对癌细胞表现出抗增殖活性,并能诱导细胞凋亡 (apoptosis)。- 高纯度,全球文献引用。 May 3, 2023 · 140 people with SPMS took either a high dose of simvastatin (80mg a day) or a placebo for two years
It belongs to a group of drugs known as "statins
Who may not be able to take simvastatin
Simvastatin is a substrate of CYP3A4 and the transport protein OATP1B1; exposure can be significantly increased with concomitant administration of inhibitors of CYP3A4 and OATP1B1; Reduce dose by 50% if initiating lomitapide; do not exceed 20 mg daily (or simvastatin 40 mg daily for patients who have previously taken 80 mg daily dosage Aug 21, 2023 · Simvastatin is a prodrug and is hydrolyzed to its active β-hydroxyacid form, simvastatin acid, after administration
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Special populations
Simvastatin belongs to a group of drugs called HMG-CoA reductase inhibitors, also known as statins
The concept of using statins to treat cancer has been adopted since the 1990s In Simvastatin 20mg tablets are used to lower cholesterol and prevent cardiovascular diseases
While rare, serious simvastatin side effects can include severe muscle damage and liver damage
La adición de colestiramina al tratamiento con simvastatin aumenta el efecto reductor de colesterol LDL en aproximadamente un 55 por ciento
Oct 25, 2023 · The bottom line
Feb 5, 2024 · Gemfibrozil — manufacturers advise avoid for atorvastatin, rosuvastatin, and simvastatin