Certain
Increased exposure to simvastatin, atorvastatin, and lovastatin when coadministered with diltiazem and verapamil has been reported
Simvastatin is used together with a proper diet to treat high cholesterol and triglyceride (fat) levels in the blood
Verapamil or diltiazem were either coincubated with simvastatin and microsomes before the reaction was initiated with an NADPH-generating system (solid symbols) or
Verapamil Diltiazem: Do not exceed 20 mg simvastatin daily: Fusidic acid: Patients should be closely monitored
What is Verapamil hcl? Verapamil hcl has active ingredients of
Theoretical How To Manage Interaction Concomitant administration of atorvastatin and verapamil may result in elevated atorvastatin levels, leading to an
Similarly, studies with diltiazem 120 mg twice daily for 10 days increased the AUC0-24h of simvastatin and simvastatic acid following a single dose of simvastatin 80 mg by 3
When verapamil was coincubated with simvastatin, IC 50 values ranged from 23 to 26 µ m for all major metabolites
Descriptions
Diltiazem has been found responsible for rhabdomyolysis secondary to interaction with simvastatin and atorvastatin (Kanathur et al
Avoid consuming grapefruit products
Ritonavir, a strong cytochrome P450 (CYP) 3A4 inhibitor and a P-glycoprotein (P-gp) inhibitor, is coadministered with nirmatrelvir to increase the blood concentration of nirmatrelvir, thereby making it effective against SARS-CoV-2
Dofetilide
reducing simvastatin dose to 20mg - most patients can be managed this way as the interaction with amlodipine leads to an increase in simvastatin exposure that is similar to taking simvastatin 40mg alone
Interaction Summary
Limit the dose of simvastatin in patients on verapamil to 10 mg daily
Constipation is the most common side effect of verapamil and it may interact with several medicines and grapefruit products
An Overview of Muscle Pain in Statin Users
There is a potential for drug-drug interactions with atorvastatin, fluvastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin so lower Many in vitro studies have investigated the drug–drug interactions of statins and CCBs