- Theophylline serum concentration should be monitored every 2 hours until declining values are confirmed
Enterohepatic recycling occurs by biliary excretion and intestinal reabsorption of a solute, sometimes with hepatic conjugation and intestinal deconjugation
It is a bronchodilator
Enterohepatic recirculation occurs when a significant amount of an NSAID or its conjugated metabolites are excreted into the bile and then reabsorbed in the distal intestine
Multiple-dose activated charcoal (MDAC) is often a consideration in cases of life-threatening ingestions of carbamazepine, dapsone, phenobarbital, quinine, and theophylline
Enterohepatic circulation is the circulation of biliary acids, bilirubin, drugs or other substances from the liver to the bile, followed by entry into the small intestine, absorption
Fractions of certain drugs absorbed from the intestine to the systemic circulation via the portal vein can return to the intestine via the bile duct and the sphincter
- Theophylline serum concentration should be monitored every 2 hours until declining values are confirmed
Multiple-dose activated charcoal (MDAC) is often a consideration in cases of life-threatening ingestions of carbamazepine, dapsone, phenobarbital, quinine, and theophylline
The investigators believe that the Large overdoses of IV theophylline (50 to 100 mg/kg) were administered to five canines on two separate occasions
A model describing enterohepatic recirculation was considered but not used as the observed secondary peaks in the study patients were considered relatively small
5)
The others — bisoprolol, chlorpropamide, diazepam, hexobarbital and theophylline —
Enterohepatic recirculation (EHC) is a common pharmacokinetic phenomenon that has been poorly modelled in animals
Bile is a greenish liquid secreted by the liver cells and stored in the gallbladder
Theophylline levels may be modestly altered in thyroid dysfunction
Ingestion of a xenobiotic known to form concretions or bezoars, such as aspirin
warfarin, digoxin or propranolol, but decreased the binding of theophylline from 53% to 45% and phenytoin from 90% to 87%
Ofparticularimportanceis thepoten-tial amplifying effect of enterohepatic variability in defining differences in the Enterohepatic recirculation (EHRC) is a multistaged process with the following sequence: liver metabolism, bile secretion, gut metabolism, and reabsorption from the gut back to the systemic circulation
In vivo, MPAG is converted to MPA via enterohepatic recirculation
Enterohepatic recirculation (EHC) concerns many physiological processes and notably affects pharmacokinetic parameters such as plasma half-life and AUC as well as estimates of bioavailability of drugs
Theophylline is a medication used to treat asthma and chronic obstructive pulmonary disease as a second-line drug