2 ng/mL had significantly better long-term survival than those with a mean
The utility of tacrolimus time in therapeutic range (TTR) after renal transplantation (RT) under an early corticosteroid withdrawal (ECSWD) protocol is
Most individuals display optimal response to tacrolimus with trough whole blood levels of 5
The target range of tacrolimus trough concentration for the first three months after lung transplantation is established at 10–15 ng/mL [ 5 ]
1 )
Tacrolimus is also used
As failure to maintain the tacrolimus trough level in target ranges is a risk factor for inferior short- and long Huang Z, Liu J, Wang Z, Li L, Zeng J, Fan Y, Wang X, Li X and Lin T (2019) Increasing Time in
Neurological symptoms (tremor, headache) • Assess tacrolimus trough level for correlation with tremors or headache • If trough level is above goal, adjust tacrolimus dose and follow up with patient • if trough level within target range, no dose adjustment is recommended, follow-up with patient in 1 week Default Therapeutic Reference Range: 5
Dosages must be tailored to the individual
Children—0
2022 Feb;42 hoc analysis revealed associations between rejection and TTR when high and low TTR groups were created at different levels
Sample type: Whole Blood Test name: Tacrolimus a
Reference range: Therapeutic Range 5 - 15 µg/L Container: EDTA (Lavender top) Ideal volume (mL): 4 mL An idiosyncratic reaction of unilateral common peroneal nerve palsy associated with below desired therapeutic range of tacrolimus level in a patient postheart transplantation Indian J Pharmacol
Tacrolimus is metabolised by the cytochrome P450 pathway, therefore drugs which affect the enzymes in this pathway may affect the tacrolimus concentration in the blood
Target therapeutic range of tacrolimus in adult renal transplant patient at MGH is 10–12 ng/mL for less than 1 month, 8–10 ng/mL for 2–3 month, 6–8
9%, respectively Background: The aim of the present study was to investigate the impact of time in therapeutic range TTR on long-term outcomes of living kidney transplants
Currently, tacrolimus (TAC) is among the most used first-line immunosuppressant drug for the prevention of post-transplantation graft rejection (Staatz et al
2
The therapeutic range established by a Tacrolimus levels were measured monthly between 6 months and 1 year
Both drugs bind with high affinity to a family of cytoplasmic proteins present in most cells: cyclophilins for With intravenous use: For intravenous infusion ( Prograf ®); manufacturer advises give continuously in Glucose 5% or Sodium Chloride 0
P = 0
6 mg/day in the 3 months following tacrolimus initiation was required (vs -1
Maintenance immunosuppressive therapy is administered to almost all kidney transplant recipients to help prevent acute rejection and the loss of the kidney allograft
The drug levels were considered to be beyond the therapeutic range in 18/22 (82%) patients