They found that all 3 drugs were superior to placebo except for the following symptom-types: duloxetine for fatigue, milnacipran for sleep disturbances, and
The therapeutic efficacy of Duloxetine can be decreased when used in combination with Gilteritinib
Descriptions Duloxetine is used to treat depression and anxiety
Duloxetine, sold under the brand name Cymbalta among others, is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive-compulsive disorder, fibromyalgia, neuropathic pain
analysed data from three randomised control trials and found no associations between the efficacy of duloxetine and the patient’s age, type or duration of diabetes The efficacy of duloxetine in treating PDPN has been demonstrated in a total of 4 RCTs conducted between 2005 and 2011 [34–37]
77,78 Chappell et al conducted a 13-week randomized, placebo-controlled trial of duloxetine (60–120 mg/day) in 174 patients (74
Abstract
The RCT (n = 43) assessing the efficacy of duloxetine in hand OA patients reported no statistically significant differences between the duloxetine and placebo groups with regard to pain, function, or depression outcomes
Aged, 80 and over
Average pain reduction was assessed over 3 months as the primary efficacy outcome
Interestingly, in one study, 30 a 20 mg dose of duloxetine appeared to offer similar efficacy to the higher doses used (60 to 120 mg)
Supportive data on the efficacy and safety of duloxetine in the treatment of older patients (≥65 years old) with GAD were provided from an analysis of 73 patients from four acute therapy, placebo-controlled trials (duloxetine n = 45, placebo n = 28) (Davidson et al
In published systematic reviews, there is no agreement about which drug is more effective and safer
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