Generic name: gemfibrozil [ jem-FYE-broe-zil ] Brand name: Lopid Dosage form: oral tablet (600 mg) Drug class: Fibric acid derivatives
001) in lowering LDLc, non-HDLc
Gemfibrozil is a useful medication for the reduction of triglycerides in patients with very high serum triglycerides levels
Gemfibrozil comes only in the form of a tablet you
We conclude that atorvastatin hydroxy metabolites, and gemfibrozil metabolite I
Gemfibrozil is the worst offender with statins and specifically contraindicated with simvastatin
When the coadministration of statins and fibrates is needed, fenofibrate
Fibrates can be prescribed with a statin, ezetimibe, or taken alone as a statin alternative
According to the FDA, concomitant (at the same time) use of atorvastatin and gemfibrozil (Lopid) increases the risk of myopathy (disease where muscle fibers malfunction) and rhabdomyolysis (condition where muscle breaks down and releases a harmful protein into the bloodstream)
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(See "Screening for lipid disorders in adults", section on 'Choice of tests' and "Atherosclerotic cardiovascular disease risk assessment for primary prevention in adults gemfibrozil atorvastatin
Atorvastatin (Lipitor) is known as a moderate-to-high-intensity statin, meaning it lowers your cholesterol more Loss of interest in sex
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Although not all of these side effects may occur, if they do occur they may need medical attention
Gemfibrozil can cause problems when used together with the statin family of cholesterol-reducing medications, for example: lovastatin (), ; pravastatin (Pravachol), ; simvastatin (), ; fluvastatin (), ; rosuvastatin (), and ; atorvastatin ; All these increase the risk of a condition called rhabdomyolysis (muscle injury) that when severe can lead to kidney damage and
This medicine may help prevent medical problems (eg, chest pain, heart attack, or stroke) that are caused by fats clogging the blood vessels
LDL oxidation induced by either copper ions (10 microM CuSO4), by the free radical generator system 2'-2'-azobis 2 Drug interactions can differ with various statins, including Crestor (rosuvastatin), Lescol (fluvastatin), Lipitor (atorvastatin), Mevacor (lovastatin), Pravachol (pravastatin), or Zocor (simvastatin)
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In rare cases, Lopid can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure
The 2 fibrates currently approved in the United States are gemfibrozil and fenofibrate