[1] The amount of urine produced can be nearly 20 liters per day
diabetes insipidus (DI) characterized by excess free water loss and dilute urine
with lithium-induced diabetes insipidus
Although often used to treat patients with a range of mood disorders, lithium has been associated with several forms of renal injury, the most prevalent of which is
Diabetes insipidus (DI) was successfully induced by Li administration for several weeks
Recent data from animal models of lithium-induced nephrogenic diabetes insipidus showed that hydrochlorothiazide reduces polyuria in mice lacking the
Hydrochlorothiazide/lithium Lithium-induced nephrogenic diabetes insipidus and lack of efficacy: case report Case report Published: 20 May 2023 Volume
A 72-year-old man developed acute kidney injury, acute nephrogenic diabetes insipidus and neurotoxicity following the concomitant use of
The major symptoms of arginine vasopressin deficiency (AVP-D), previously called central diabetes insipidus [ 1 ], are polyuria, nocturia, and polydipsia due to the concentrating defect
Blocking lithium entry with Desmopressin is used to treat diabetes insipidus of the central nervous system
Intracerebral calcification, seizures, psychosomatic retardation, hydronephrosis, and hydroureters are Clinical definition
Failure to produce antidiuretic hormone (ADH) Insensitivity or resistance of the kidneys to ADH
For long-term In rates with lithium-induced nephrogenic DI, HCTZ reversed lithium-induced downregulation of AQP2
Food and Drug Administration (FDA) to treat hypertension and peripheral edema
She was hospitalized due to disturbance of consciousness and was diagnosed with, hypercalcemia, hyperparathyroidism, and NDI
Diabetes insipidus means the excessive production of dilute urine; the term diabetes indicates excessive urine production (Greek: διαβετεσ = siphon), and the term insipidus implies “tasteless,” in contrast to the taste of urine from patients with diabetes mellitus
Arch Dis Child
Diabetes insipidus (DI) is a temporary or chronic disorder characterized by the excretion of excessive quantities of very dilute, but otherwise normal urine
As a result, patients with this disorder are not likely to have a good response to hormone
Rationale:Hyperglycemia can occur as a result of the administration of growth hormone, particularly in a client with diabetes mellitus
1
Previous studies have reported that downregulation of aquaporin-2 (AQP2) is important for the development of lithium
Grünfeld JP, Rossier BC
A 72-year-old man developed acute kidney injury, acute nephrogenic diabetes insipidus and neurotoxicity following the concomitant use of lithium and hydrochlorothiazide [ routes not stated ]
Hydrochlorothiazide attenuates lithium-induced nephrogenic diabetes insipidus independently of the sodium-chloride cotransporter
I don't undersand the mechanism of how Hydrochlorothiazide is used to treat nephrogenic diabetes insipidus
Lithium carbonate is a well documented cause of nephrogenic diabetes
It also causes a feeling of being very thirsty even after having something to drink