Food and Drug Administration
Gastroparesis is a syndrome of objectively delayed gastric emptying in the absence of a mechanical obstruction and cardinal symptoms of nausea, vomiting, early satiety, belching, bloating, and/or upper abdominal pain
There are 2 other drugs that may
Acute hyperglycemia may impair gastric motor function as well as inhibit the action of prokinetic drugs, such as erythromycin
Medical treatment detailed the use of prokinetic and antiemetic therapies including metoclopramide, short-term use of erythromycin, and gastric electrical stimulation
Erythromycin is a macrolide antibiotic that is licensed for treating and preventing infections
Erythromycin mimics the effect of the gastrointestinal polypeptide motilin on gastrointestinal motility, probably by binding to motilin receptors and acting as a motilin
Erythromycin Metoclopramide Both agents facilitate tolerance to intragastric EN, but erythromycin may be more effective than metoclopramide for enhancing gastric motility
Erythromycin (EM) is a well-known prokinetic agent
Motilin stimulates gastric and small intestine
It interferes with the muscle activity ( peristalsis) that moves food through your
This includes respiratory tract infections, skin infections, chlamydia infections, pelvic inflammatory disease, and syphilis
The other studies identified in the systematic review did not provide reliable evidence of
Erythromycin accelerates gastric emptying of both liquids and solids, and expels these two components at a similar speed
Objective: To document the action of erythromycin on gastric emptying and motility in mechanically ventilated patients
Management of gastroparesis should include assessment and correction of nutritional state, relief of symptoms, improvement of gastric emptying and, in diabetics, glycemic control
each; n = 60 patients) both increased gastric emptying in patients with gastroparesis
, 1993b; Thielemans et al
, 1993b; Thielemans et al
It has been shown to enhance antral contractility and accelerates gastric emptying rates, primarily by stimulating motilin receptors
Gastroparesis (literally “gastric palsy”) (Gp) is a pathological condition characterized by objectively demonstrated delayed or absent emptying of the stomach in the absence of mechanical obstruction[1,2]
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36 In a series comparing metoclopramide with erythromycin, the two agents had similar effects on gastric emptying but erythromycin had a more pronounced effect on symptom relief
PARENTERAL: Erythromycin Lactobionate (Lactobionate): 15 to 20 mg/kg IV per day via intermittent IV infusion over 20 to 60 minutes no more than every 6 hours or via slow continuous IV infusion
stomach cramp or tenderness