This recommendation is based on findings from 30 trials with more than 10 000
The antimalarial drug hydroxychloroquine (HCQ) is among the much-discussed drugs for the treatment and management of COVID-19 patients
High doses may therefore be useless or even deleterious because of the anti-interferon action of hydroxychloroquine, 5 which may result in a more severe
Hydroxychloroquine has been widely administered to patients with Covid-19 without robust evidence supporting its use
Outcomes Related to COVID-19 Treated with Hydroxychloroquine among In-patients with Symptomatic Disease (ORCHID) STATISTICAL ANALYSIS PLAN (SAP)
Hydroxychloroquine as Postexposure Prophylaxis for Covid-19
A recent study by French researchers suggests that nearly 17,000 people across six countries may have died due to Hydroxychloroquine, prescribed during the first wave of
8%]) and
It's used to reduce fever and inflammation, and the hope has been that it can also For hospitalized patients with COVID-19 who have evidence of pneumonia, we suggest hydroxychloroquine (or chloroquine) on a case-by-case basis
We systematically reviewed the existing clinical evidence of HCQ use for the prevention and
, “COVID-19”, “HCQS and azithromycin”, or “SARS-COV-2”) and retrieved all articles published in the English language that reported efficacy, safety, clinical outcome, and pharmacology for
Some preliminary reports have suggested that hydroxychloroquine
There have been several studies of hydroxychloroquine and COVID-19 and at this time the best
We found no evidence of a difference in COVID-19 mortality among people who received hydroxychloroquine for treatment of rheumatological disease before the COVID-19 outbreak in England
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the global, rapidly emerging virus causing coronavirus Hydroxychloroquine was found to reduce mortality in healthy, SARS-Cov-2 positive patients and improve clinical recovery in renal transplant recipients
These drugs are no longer recommended for emergency use in hospitalized patients with COVID-19
Hydroxychloroquine showed promise in studies done in test tubes rather
Chloroquine and hydroxychloroquine are anti-malarial medications also used against some auto-immune diseases
Abbreviations: HCQS-Hydroxychloroquine, CQ-Chloroquine, SARS-CoV-2- severe acute respiratory syndrome coronavirus 2, COVID-19- Coronavirus disease 2019, FDA- Food and Drug Administration, ICMR-Indian Council of Medical Research, WHO-World Health Organization, RCT-Randomized controlled trial
We sought to determine whether hydroxychloroquine (HCQ) application may reduce the death risk of critically ill COVID-19 patients