ZOFRAN
Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting
Its efficacy for the treatment of acute gastroenteritis (AGE) in children is well-established
Ondansetron
Take this medication
A subsequent RCT (N = 176) found that ondansetron use led to significantly fewer failures of oral rehydration (12 of 82 children receiving ondansetron vs
ACTION: Notice
Ondansetron AN ODT is available as orally disintegrating tablets containing 4 mg and 8 mg ondansetron
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Ondansetron is a 5-HT 3 receptor antagonist indicated for the prevention of:
The firm offered to make available whatever data it had that might be useful to the Subcommittee
Chemotherapy-Induced Nausea and Vomiting: Highly Emetogenic Chemotherapy: In 2 randomized, double-blind, monotherapy trials, a single 24 mg ondansetron tablet was superior to a relevant historical placebo control in the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy, including
The intravenous dose must not exceed 8 mg
6 m 2) 2 mg every 12 hours for up to 5 days (dose can be started 12 hours after intravenous administration); maximum 32 mg per day
It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting
Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy
The neurotransmitter, serotonin, appears to play a role in ondansetron's effect
Ondansetron is a widely used 5-hydroxytryptamine-3 receptor antagonist which has been demonstrated to reduce vomiting, intravenous fluid rehydration, and hospitalization in clinical trials of children with acute gastroenteritis (AGE)
Comment: Ondansetron inhibition of transporters (MATE or OCTs), which are responsible for active renal secretion of metformin may play a role
Use alternatives if available It is indicated for the prevention and treatment of nausea and vomiting related to chemotherapy or radiotherapy, as well as post-operative nausea and vomiting, in children age 4-18 and adults
Ondansetron may also be used for vertigo or a spinning feeling in children
5-2 hours prior to chemotherapy
How to The active ingredient in Ondansetron Tablets, USP is ondansetron hydrochloride (HCl) as the dihydrate, the racemic form of ondansetron and a selective blocking agent of the serotonin 5-HT
Important: The patient should not push the tablets through the foil top like a usual tablet, as this will crush it