For treatment of chronic muscle pain: Adults—60 milligrams (mg) once a day
Nausea, dry mouth, constipation, loss of appetite, tiredness, drowsiness, or increased sweating may occur
Core tip: Long QT syndrome is a cardiac conduction disorder characterized by prolongation and increased dispersion of ventricular repolarization, manifested by lengthening of the QT interval on the surface electrocardiography
The electrophysiological effects of duloxetine at supratherapeutic exposures were evaluated to ensure compliance with regulatory criteria and to assess the QT
A vital
Fluoxetine, fluvoxamine, and sertraline at traditional doses demonstrate a lack of clinically significant increases in QTc in the majority of studies
With
The QT interval, most often reported as the corrected (for heart rate) QT interval or QTc, is an electrocardiographic measure of ventricular repolarization and
QT prolongation can remain asymptomatic or lead to torsades de pointes (TdP), a rare tachyarrhythmia which can be life-threatening or nearly fatal due to ventricular fibrillation
Sex problems like lowered interest in sex or ejaculation problems
Other antidepressant options, namely bupropion or mirtazapine may be considered since they carry minimal to no risk of QT prolongation
Maximum dose: 120 mg/day
Oral route (Capsule, Delayed Release) Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults in short-term studies
15 Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major
Pharmacokinetics
depression – the starting dose is 60mg, taken once a day and this can be increased to 120mg, taken once a day
It may take longer if you're taking it for nerve pain
2 A number of drugs have been implicated in prolongation of the QT interval, including anti- Duloxetine is used to treat depression and anxiety
日本での適応は、うつ病・うつ状態に加え、糖尿病性神経障害・神経因性疼痛・線維 Common side effects may include: drowsiness; nausea, constipation, loss of appetite; dry mouth; or
The risk of drug-induced prolongation of QT is much higher in older adults and people with multiple
Venlafaxine may also increase the risk of QT interval prolongation if taken concomitantly with an SSRI
These common side effects of duloxetine can happen in up to 1 in 10 people
It is not meant to be comprehensive and should be used as a tool to help the user understand and/or
However, the QT interval varies inversely with heart rate, so a correction for heart rate typically is calculated using Bazett’s formula: QTc = QT interval ÷ the square root of the