1582-4934
Simvastatin is an oral HMG-CoA reductase inhibitor indicated as an adjunct to diet
Description Simvastatin is a member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group
Introduction
The use of statin was significantly associated with a lower adjusted risk of
Abstract Background and purpose: The effectiveness of hyperlipidemia treatment in
Statins competitively inhibit
Statins are reversible and competitive inhibitors of HMG-CoA reductase, which is the rate-determining enzyme in the cholesterol biosynthetic pathway []
Vytorin Versus Atorvastatin Study: LDL-C reductions
Thus, the reduction of LDL-C levels is a major target for the prevention of cardiovascular disease
4% relative risk reduction in the only large clinical outcomes trial in which it was tested, and is recommended for high-risk patients with an inadequate response to statins, despite the high number needed to treat to prevent 1 CV event
Background: Porokeratosis is associated with mevalonate pathway gene mutations
Preclinical and epidemiologic studies suggest a protective effect of statins on Alzheimer disease (AD)
Zebrafish larvae were fed a HCD for 14 days
The administration of high-intensity statins suppresses cholesterol synthesis and may trigger the onset of diabetes mellitus
Statins are the most effective low density lipoprotein-cholesterol (LDL-C) lowering medications available and have been strongly associated with a reduced risk of atherosclerotic CVD
Background: Atorvastatin, a new enantiomerically pure synthetic statin, has shown a marked low-density lipoprotein (LDL) cholesterol reduction at doses ranging from 10 to 80 mg/d
1,2 Taken together, several large
Grapefruit juice may increase both the cholesterol-lowering effect and the risk of adverse effects of simvastatin
12 In spite of other extra-hepatic tissues, most of studies have shown the negative effects of statins on the ABCAI and ABCG1 expression in cultured macrophages
Typically, these statins need to be taken in doses of 40–80 mg daily to exceed a 30% reduction in LDL cholesterol levels ( Jones et al 1998 )
In studies, statins were found to lead to high blood sugar levels in 1 out of 1,000 people per year