Azathioprine is chemically 6-[(1-methyl-4-nitro-1 H-imidazol
Thiopurines (ie, azathioprine [AZA] and mercaptopurine, also known as 6-mercaptopurine, [6-MP]) exert a glucocorticoid-sparing effect for patients with inflammatory bowel disease (IBD) who cannot maintain remission when glucocorticoids are tapered and withdrawn
5 mg/kg once daily
In this study, patients were randomized to receive either infliximab alone, azathioprine alone, or the combination of infliximab and azathioprine
Azathioprine has a complex metabolism, leading to variable response and metabolite profiles in individual patients and the need to personalise dosage
5 mg per kg with 6-mercaptopurine
Milyen az Imuran külleme és mit tartalmaz a csomagolás
It is also used to relieve joint pain and swelling for patients with active rheumatoid arthritis
Previous reports indicate that 6-thioguanine nucleotide (6-TGN) levels correlate with therapeutic efficacy, whereas high 6-methylmercaptopurine (6-MMP) levels are associated with hepatotoxicity
The dose of thiopurines may vary between people and over time
Children over 12 years: 2 mg/kg/day orally with or without low-dose corticosteroids; Crohn's Disease (Off-label) Maintenance, remission, or reduction of steroid; 2-3 mg/kg 4
13 From an IBD patient's perspective, prolonged clinical
Intensive dosing regimens included either shortened interval between the infliximab dosing (<2 weeks, dose stacking) and/or induction with higher-dose infliximab (10