CrCl ; 30 mL/min: Do not use 875/125 mg tablet or extended-release tablets CrCl 10-30 mL/min: 250-500/125 mg PO q12hr Patients with Renal Impairment Patients with impaired renal function do not generally require a reduction in dose unless the impairment is severe
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Renal Impairment: Amoxicillin is primarily removed from the body by the kidney, and dosage adjustment is recommended in patients with severe renal impairment (CrCL<30 Drug Summary What Is Augmentin? Augmentin ( amoxicillin /clavulanate) is a combination antibiotic used to treat bacterial infections including sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin
Dosage forms: TAB: 250 mg/125 mg, 500 mg/125 mg, 875 mg/125 mg; SUSP: 125 mg/31
Each tablet contains 875 mg amoxicillin as the trihydrate, 125 mg clavulanic acid as clavulanate potassium
Augmentin is available as a lower-cost generic
4, 8
Avoid use during 1st trimester of pregnancy
40 mg/kg/day in divided
Augmentin Duo tablets should be used with care in patients with moderate or severe renal impairment
Paediatric use
4) • The severity and the site of the infection • The age, weight and renal function of the patient as shown below
4 mg/kg/day given in 2 divided doses
250 mg/62
2 Dose and method of The effects of many drugs get altered in renal impairment particularly when a drug has renal clearance
Accumulation of sodium from injection can occur in patients with renal impairment
Neither component in AUGMENTIN is highly protein-bound; clavulanic acid has been found Table of Contents Page 2 of 9 ANTIBIOTICS 1CrCl > 150 mL/min CrCl 30-49 mL/min CrCl1 10-29 mL/min CrCl1 < 10 mL/min; HD2 CRRT (rate 2
V
50 mg/kg/dose q6h
5 mg/kg/dose bid The dose of Augmentin that is selected to treat an individual infection should take into account: • The expected pathogens and their likely susceptibility to antibacterial agents (see section 4
* Each 30 mg AUGMENTIN contains 25 mg amoxicillin and 5 mg clavulanate
The presence of clavulanic acid in amoxicillin-clavulanate may cause a non-specific binding of IgG and albumin by red cell membranes leading to a false positive Coombs test
3 mg (1
A qualified person, like a doctor or a nurse, will give you this Draw peak 30 min after infusion ends Once daily dosing: goal peak 35 - 60 mcg/mL; goal trough < 4 mcg/mL Conventional dosing: goal peak 25 - 35 mcg/mL for serious infections; 15 - 20 mcg/mL for UTI; goal trough < 4 - 8 mcg/mL
ACE Inhibitor s or Angiotensin Receptor Blocker s (ARB) Preferred agents in CRF (renal and cardioprotective) Starting dose
AUGMENTIN should be avoided if infectious mononucleosis is suspected since the occurrence of a morbilliform rash has been associated with this condition following the use of amoxicillin
21±3
Postmenstrual age greater than 40 weeks: 10 mg/kg IV every 8 hours
Gestational age greater than 34 weeks: Postnatal age up to 28 days: 50 mg/kg IM or IV every 8 hours
Mechanism of Action 12
Experience with the 200 mg/5 mL formulation in this age group is limited, and thus, use of the Amoxicillin (AMX) has been associated with acute kidney injury (AKI)
Dosing regimens should be tailored based on presumed source of infection, MIC data (when available), and residual renal function
Amoxicillin is primarily eliminated by the kidney and dosage adjustment is usually required in patients with severe renal impairment (GFR less than 30 mL/min)
73m2) or calculated CrCl ( ml/min) 30 - 50 10 - 30 <10 Amoxicillin No adjustment required Max
Each mL of suspension will then contain amoxicillin trihydrate equivalent to 50 mg amoxicillin
23 mL
Refer to renal pharmacist for advice on dosing in haemodialysis and peritoneal dialysis
Effects on laboratory tests