Rosuvastatin has been available since 2003 and is used by 12 million people worldwide
patients with COVID-19 with cardiovascular diseases are recommended to discontinue rosuvastatin or to increase
It suggests that fewer drug interactions resulting from cytochrome P450-mediated metabolism should be expected with rosuvastatin compared with other
1 Atorvastatin-induced muscle-related adverse effects may be influenced by the activity of
While present in most body tissues, CYP enzymes predominantly occupy the liver, intestines, and kidneys, with their highest concentration in the liver
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fluvastatin (Lescol), and rosuvastatin (Crestor) are unaffected by grapefruit
Statins also have different affinities for membrane Drugs used in HIV, especially drugs from the PIs, the NNRTIs, and the INSTIs classes are metabolized via the Cytochrome P450 (CYP) pathway [7, 8]
Concerning rosuvastatin, it is well-known that it neither undergoes metabolism via the cytochrome P450 nor transports through P-glycoprotein
(rosuvastatin [76% of prescriptions], pravastatin [21%] or fluvastatin [3%]) between 2002 and 2013 and were newly prescribed clarithromycin The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids