For the best compound of the series, the 3- (4-methoxyphenyl)-6-nitrocoumarin (4 ), the IC 50 value, type of inhibition, cytotoxicity on B16F10
It belongs to a class of drugs called xanthine oxidase inhibitors, which reduce uric acid levels by blocking a specific protein in the body
Despite being a good
About allopurinol
Allopurinol, a xanthine oxidase inhibitor, has been in clinical use for over 40 years in the treatment of chronic gout
Allopurinol is metabolized to oxypurinol which is also an inhibitor of xanthine oxidase; allopurinol acts on purine catabolism, reducing the production of uric acid without disrupting the
Thus enzyme inhibition becomes stronger and maximum velocity cannot be reached
aeruginosa infection
More recent data indicate that XO also plays an important role in various forms of ischemic and other types of tissue and vascular injuries, inflammatory Since allopurinol is a suicide inhibitor of XOD and the inhibition develops time-dependently , so the IC 50 value of allopurinol was calculated for the late phase as well by carrying out the reaction for 60 min and the IC 50 values of allopurinol for XOD corresponding to the substrates hypoxanthine and xanthine were 0
In 2009 it was shown that induction of Cbl-b (a RING-type ubiquitin ligase) in vivo was required for the loss of muscle mass in response to Stereoisomers of Soman, a G-series nerve agent and suicide inhibitor of acetylcholinesterase
Allopurinol injection is used to treat high levels of uric acid (a natural substance that builds up in the blood as tumors break down) in people with certain types of cancer who are being treated with chemotherapy medications who cannot take oral allopurinol
To date, the only commercially available XO inhibitor is allopurinol, a purine analogue in clinical use for more than 30 Allopurinol was found to have a statistically significant benefit on endothelial function in patients with CHF and CKD but not in type 2 DM
444), respectively
They have mainly been tested in the elderly, in patients affected by chronic diseases such as heart failure and cancer, and in Allopurinol, a competitive xanthine oxidase inhibitor, in addition to reducing serum uric acid levels, can act as a free radical scavenger
However, other chemicals can transiently bind to an enzyme, these are called reversible
Allopurinol and its major metabolite oxypurinol inhibit xanthine oxidase (XO), the enzyme responsible for the formation of uric acid from hypoxanthine and xanthine (Pacher et al
It is not indicated for use in asymptomatic hyperuricemia ( 1 )
A high uric acid level can cause gout or gouty arthritis (joint pain and inflammation)