Minocycline also promotes neurogenesis via
The appropriate control of microglial activation may thus be a promising therapeutic target for schizophrenia
Its efficacy has therefore been
Treatment options for multidrug resistant Acinetobacter baumannii strains (MDR-AB) are limited
These results further support the microbiome-gut-brain axis as potential target in the treatment of depression
7–12 Minocycline is Minocycline Augmentation of Pharmacotherapy in Obsessive-Compulsive Disorder: An Open-Label Trial
J Clin Psychiatry 2010; 71:138–149Crossref, Medline, Google Scholar
7 Department of Pyschiatry, Dow University of Health Sciences, Minocycline, sold under the brand name Minocin among others, is a tetracycline antibiotic medication used to treat a number of bacterial infections such as pneumonia
The groups did not differ in the rate of serious adverse events (n=11 in placebo group and n=18 in the minocycline group), which were mostly due to admissions for worsening psychiatric state (n=10 in the placebo group and n=15 in the minocycline
More work is needed to improve evidence for definitive conclusions but minocycline also appears to be promising for the treatment of psychiatric disorders in particular
doi:
The effects of minocycline, escitalopram, or the combination on microglial quantity in infralimbic/prelimbic PFC slices were assessed using Iba-1 as a marker of both resting and reactive microglia
Translational Psychiatry - Neuroinflammatory alterations in Psychiatric adverse events were included as a subheading in the search results for individual antibiotics
We searched PubMed with the terms “minocycline” and “schizophrenia” or “psychosis”, filtering for “clinical trial”, on Aug 20, 2018