Initial bolus of conventional versus high-dose
In rats with a compressed spinal cord, a dose-related reduction in K was observed 6 hours after the onset of dexamethasone treatment
Neoplastic epidural spinal cord compression (ESCC) is a common complication of cancer that can cause pain and potentially irreversible loss of
In cancer patients with clinical suspicion of spinal cord compression, dexamethasone should be initiated followed by surgical decompression, when possible, and radiation
There are a number of ways to treat the pain caused by MSCC and by the cancer in other parts of your body, including pain-relieving drugs
Metastatic spinal
Metastatic spinal cord compression (MSCC) is a well-recognised complication of cancer and usually presents as an oncological emergency
Consider prophylactic gastroprotection whilst patient on high dose steroids ( omeprazole oral 20mg daily or lansoprazole
We randomly assigned dexamethasone in an initial bolus of 10 mg IV or 100 mg IV followed by 16 mg daily orally to 37 patients with metastatic spinal cord compression
8 at 3 hrs, 2
Clinical guideline [CG75] Published: 26 November 2008
(morning and lunch time)) MSCC is the compression of the spinal cord, or cauda equina, by direct pressure and/or vertebral collapse as a result of metastatic spread that may cause neurological deficit and paralysis
4 Spinal metastases and metastatic spinal cord 5 compression 6 Draft for consultation, March 2023 7 This guideline covers recognition, referral, investigation and treatment of spinal metastases and associated metastatic spinal cord compression (MSCC)
Offer corticosteroids and analgesia and consider spinal stability while the patient is
Metastatic spinal cord compression (MSCC) is a well recognised complication of the spread of cancer to the vertebral column
Spinal metastases are the most common tumors of the spine, comprising approximately 90% of masses encountered with spinal imaging
compared high dose dexamethasone to low dose dexamethasone( Graham 2006 and Vecht 1989)
MESCC is a common complication of malignancy that affects almost 5% of patients with cancer
1 Among all cancer patients, spinal cord compression due to epidural tumor metastasis is estimated to develop in 5% to 14% of cases
Thus, ideally, the dose of dexamethasone should be discontinued after 2–4 weeks