ribavirin must be used in combination with
Pegylated interferon α (IFNα) in combination with ribavirin is currently recommended as a standard-of-care treatment for chronic hepatitis C virus (HCV)
Since ribavirin is almost always used in combination with interferons, it can be difficult to know whether adverse events, if drug-induced, are due to one or the other
Recent discovery of potent inhibitors Treatment with pegylated interferon (Peg-IFN) and ribavirin (RBV) is considered as the standard treatment for hepatitis C associated with SVR in 40-50% and up to 80% of HCV genotype 1 and 2/3 (naïve) patients, respectively (6-8)
HCV infection can be an opportunistic infection (OI) of HIV
Inosine monophosphate dehydrogenase (IMDH) is required for one of the metabolic pathways of azathioprine
Some side effects were common to both interferons and ribavirin: rash with flaky, dry skin
Chronic hepatitis C With the combined ribavirin/peginterferon treatment, more than 75% of nongenotype 1 HCV patients maintain a sustained anti-HCV response, and up to 50% of the patients infected with the genotype 1 HCV responded to this combined treatment; in those patients responding to peginterferon/ribavirin therapy, virus-induced liver damage failed
Peginterferon alfa and ribavirin for the treatment of chronic hepatitis C (September 2010) Recommended with restrictions
Ombitasvir plus paritaprevir plus ritonavir with or without ribavirin in treatment-naive and treatment-experienced patients with genotype 4 chronic hepatitis C virus infection (PEARL-I):
Ribavirin is an antiviral medication used to treat hepatitis E virus infection on its own and occasionally to treat hepatitis C virus infection in combination with other medication (ribavirin must not be used on its own to treat hepatitis C)
Sustained virological responses (SVRs) rate is
Initial treatment of HCV infection includes patients with chronic hepatitis C who have not been previously treated with interferon, peginterferon, ribavirin, or any HCV direct-acting antiviral (DAA) agent, whether investigational, or US Food and Drug Administration (FDA) approved
Like interferon, it is associated with several adverse effects