As a partner drug with amphotericin B, flucytosine was superior to fluconazole (71 deaths [31
77 to 1
Fluconazole and 5-flucytosine treatment had lower total adverse events (19
1% vs 90
) and Cryptococcus gattii ( C
The results suggest that optimal oral treatment for cryptococcal meningitis is high-dose
001)
or oral fluconazole vs i
Side effects include headache, nausea, abdominal pain, diarrhea, indigestion, and more
Fluconazole was associated with less toxicity than amphotericin B/5-flucytosine
Fluconazole and 5‐flucytosine had relatively high efficacy with few adverse events in treating CM
These drugs have markedly changed the In another recent study, highdose fluconazole (800 mg) plus amphotericin B (0
Itraconazole, voriconazole, posaconazole and isavuconazole are metabolised in the liver
Nevertheless, it remains a cornerstone for induction therapy of cryptococcal meningitis, in combination with either a polyene (amphotericin B deoxycholate, liposomal amphotericin B) or fluconazole
051 times the human dose) administered on days 7 to 13 of gestation At higher doses (700 mg/kg/day; 5208 mg/m2/day or 0
Fluconazole and 5-flucytosine had relatively high efficacy with few adverse events in treating CM
1%) vs
Because of its small molecular size and low protein binding, it may be more useful in treating CNS mycoses
62; 95% CI, 0
09)