Methylprednisolone hemisuccinate is a water soluble corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders
It classifies the drug substance / active pharmaceutical ingredient (API) into four classes as below: Class 1: High Solubility – High Permeability H372 (92
A biowaiver is applicable when
Structural class Class A: Hydrocortisone type Class B: Triamcinolone acetonide type Class C: Betamethasone type Class D1: Betamethasone dipropionate type Class D2:
Correspondence to: D
The Biopharmaceutics Classification System (BCS) is a scientific framework that is based on the aqueous solubility and intestinal permeability of the drug
Online BCS Classification Database
It relieves inflammation (swelling, heat, redness, and pain) and is used to treat certain forms of arthritis; skin, blood, kidney, eye, thyroid, and intestinal disorders (e
Absolute bioavailability of
SLE 20-100 mg
Methylprednisolone is absorbed from the gastrointestinal tract with peak plasma concentrations being achieved after around 2 h (Geister et al
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Barends (Telephone: þ31 30 2744209; Fax: þ31 30 2744462; E-mail: Dirk
However, Vogt et al
The intestinal permeability classification
) Purpose To provide whole-body physiologically based pharmacokinetic (PBPK) models of the potent clinical organic anion transporter (OAT) inhibitor probenecid and the clinical OAT victim drug furosemide for their application in transporter-based drug-drug interaction (DDI) modeling
In 1995, Wu and Benet reviewed 131 drugs that had been classified into the four BCS categories in the literature through the end of 1994
Super potent (class 1 USA, class 1 UK) However, this decrease was found to be equivalent to that observed for methylprednisolone aceponate 0
Methylprednisolone aceponate (MPA) has been shown to provide rapid, reliable and highly effective treatment of eczematous disorders, with an efficacy comparable to that of most reference topical corticosteroids
It relieves inflammation (swelling, heat, redness, and pain) and is used to treat certain forms of arthritis; skin, blood, kidney, eye, thyroid, and intestinal disorders (e
Endocrine Disorders
This medicine is available only with your doctor's prescription
Procaterol is a long-acting beta-2-adrenergic receptor agonist
BCS classification system is an important tool for generic drug development