Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited genetic disorder that can result in destruction of red blood cells (hemolysis) after an acute illness or use of
To make sure phenazopyridine is safe for you, tell your doctor if you have: liver disease; diabetes; or
G6PD deficiency is an X-chromosome linked disorder
a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency
It occurs when a person is missing or has low levels of the enzyme glucose-6-phosphate dehydrogenase
Tables provided in the main manuscript of the guideline: Table 1
Recommended therapeutic use of high risk drugs in relation to G6PD phenotype
A case in which symptoms of pheny toin toxicity began two weeks after the initiation of amiodarone therapy and continued to increase until the phenytoin dose was reduced four weeks after concurrent therapy began, and a rapid resolution of all symptoms of toxicity followed
In our study, we identified more female patients with G6PD deficiency than males
Symptoms of diabetic ketoacidosis include nausea, vomiting
Have G6PD deficiency or also known as glucose-6-phosphate dehydrogenase, a genetic enzyme deficiency
The amount of hemolysis depends on the degree of G6PD deficiency and the oxidant potential of the drug
Therefore, vigilance toward possible G6PD deficiency is warranted when prescribing these medications in the primary care setting
The monomer of G6PD is composed of 515 amino acids with a molecular weight of about 59 kDa (Cappellini and Fiorelli, 2008)
Phenazopyridine is a local anesthetic used for the symptomatic relief of pain, burning, urgency, Red blood cell G6PD deficiency may increase the risk of hemolysis, and even normal doses can lead to methemoglobinemia in patients with this condition
Proper Use
In areas with high prevalence of G6PD deficiency, ascorbic acid (vitamin C) can be given
G6PD deficiency is a hereditary • phenazopyridine • primaquine • quinine • sulfacetamide • sulfadiazine • sulfamethoxazole (co-trimoxazole, septra) • sulfanilamide Phenazopyridine may interfere with glucose oxidase reagents (Clinistix, Tes-Tape) and urine ketone tests (Acetest, Ketostix)