Adult Pediatric
Breastfeeding
(1, 6) Lozanoc capsules: Note: Doses below refer to the Lozanoc brand of itraconazole only • Usual dose: 2
Treatment of Aspergillosis contraindicated during and x2wk after itraconazole tx if mod-severe renal or hepatic impairment; otherwise, avoid combo in peds pts 35 kg, adjust max fesoterodine dose to 4 mg/day in adults and peds pts >35 kg: combo may incr
Terbinafine has been used in adults with a dosage of 250 mg/day for two weeks or 500 mg daily for one week on and three weeks off for three to four months
Background: Itraconazole is a broad-spectrum antifungal agent used for prophylaxis and treatment of fungal infections in immunocompromised children
The profiles of adverse events induced by itraconazole Pediatric Use: The efficacy and safety of itraconazole have not been established in pediatric patients
Oropharyngeal candidiasis in patients with AIDS or neutropenia for itraconazole The recommended pediatric dose is 5 mg/kg/day given continuously or by repeat pulsing
The pharmacokinetic profile of posaconazole in children has been assessed in a study of 14 patients (mean age 6
Very rare cases of serious hepatotoxicity, including some cases of fatal acute liver failure, have been reported with the use of Itraconazole
2%: $100 ($4,500) Itraconazole (Sporanox) Fingernails: Two treatment pulses of 200 mg twice daily for one week separated by three weeks without 10
3 The recommended dose of itraconazole continuous therapy for pediatric patients is 3-5 mg/kg/d
PK/PD Itraconazole answers are found in the Johns Hopkins ABX Guide powered by Unbound Medicine
ADVERSE DRUG REACTIONS
We studied itraconazole use and treatment outcomes in a tertiary Includes Itraconazole indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more
1 Administration; 2 Adult Dosing; 3 Pediatric Dosing; 4 Special Populations
This finding was not observed in the mouse carcinogenicity study at doses of 500, 2,000 or 5,000 mg/kg/day for 22 to 23 months
Avoid getting pregnant while taking itraconazole and for 2 months after your last dose
5 times the MRHD)
Oral itraconazole in doses of 100 mg/d for 2 weeks shows high efficacy
Oral: 9 mg/kg orally every 12 hours
Tinea of hands & feet: 1 capsule (100 mg) daily for 4 weeks
3 The recommended dose of itraconazole continuous therapy for pediatric patients is 3-5 mg/kg/d
Few side effects were seen in most studies using 3 mg/kg/day to 5 mg/kg/day for four to six weeks
Pediatric infectious diseases: Martin B Pharmacokinetics and Metabolism General Pharmacokinetic Characteristics Peak plasma concentrations of itraconazole are reached within 2 to 5 hours following oral administration
For itraconazole, 6 studies used daily continuous regimen and 3 studies (2 with capsules, 1 with oral solution) used a pulsed regimen
Itraconazole was administered once per month for 6 months as relapse prophylaxis (200 mg twice a day)
Itraconazole 5 mg/kg/day (maximum dose 400 mg daily) Using 100 mg capsules $$$$ Using 10 mg/mL liquid $$$$$ Terbinafine For a child under 20 kg: 62
Tinea capitis primarily occurs in children
Do not use in patients with pneumonia who may be inappropriate for oral therapy because of moderate to severe illness or risk factors such as any of the following: Patients with cystic fibrosis The efficacy and safety of itraconazole have not been established in pediatric patients
i
ketoconazole will increase the level or effect of maraviroc by P-glycoprotein (MDR1) efflux transporter
2 to 5 mg/kg/d in 1 to 2 divided doses (max dose 400 mg/day) Should only be used on ID recommendation
Loading dose: 200 mg orally 3 times a day for the first 3 days of therapy 2
Dosage Forms & Strengths capsule
Recommended dose 130 mg (2 x 65 mg capsules) once daily If no obvious improvement
Pityriasis versicolor: 200 mg/day for 10 days, with a preventative dose of 200mg once
It belongs
Initial load: 2
2 weeks or younger (gestational age 26 to 29 weeks): 3 mg/kg IV or orally every 72 hours drug should only be used for treatment of less severe disseminated infection in moderately ill patients intolerant of itraconazole
Fluconazole use requires caution in patients with liver dysfunction, given its
1 Administration; 2 Adult Dosing; 3 Pediatric Dosing; 4 Special Populations
This finding was not observed in the mouse carcinogenicity study at doses of 500, 2,000 or 5,000 mg/kg/day for 22 to 23 months
The solution should be vigorously swished in the mouth (10 mL at a time) for several seconds and swallowed
” The capsules are supplied in bottles of 30 capsules (NDC 49884-239-11)
The long-term effects of itraconazole on bone growth in children are unknown
Inactive ingredients are hard gelatin capsule, hypromellose, polyethylene glycol (PEG) 20,000, titanium dioxide, FD&C Blue No
The pharmacokinetic profile of posaconazole in children has been assessed in a study of 14 patients (mean age 6
3 to 6
Stop using itraconazole and call your doctor at once if you have signs of congestive heart failure: feeling tired or short of breath, cough with mucus, fast heartbeats, swelling, rapid weight gain, or sleep problems
Medical professionals in the paediatric sector have access to dosage recommendations that have been developed in a standardised harmonisation process throughout Switzerland
During the 1-week pulse of active therapy, itraconazole (5 mg/kg/day) was dosed as follows: more than 40 kg, 200 mg per day (two capsules per day); 20 to 40 kg, 100 mg per day (one capsule per day); and 10 to 19 kg, 50 mg per day (one half of a capsule per day)
Eye infections: 2 capsules (200 mg) daily for 3 weeks
For very young patients who Itraconazole oral solution is only used to treat oropharyngeal or esophageal candidiasis (thrush, oral thrush)