Maintenance dose of phenytoin
Concomitant use of phenytoin with multiple doses of cenobamate 200 mg qDay increased phenytoin mean Cmax and AUC by 70% and 80
Therapeutic drug monitoring of phenytoin is carried out to ensure effective and safe levels
To minimize risk of PGS or other types of soft-tissue
- Phenytoin injection should be injected slowly and directly into a large vein through a large-gauge needle or intravenous catheter at a rate not exceeding 50
Children 6 years of age and younger—Dose is based on body weight and must be determined by your doctor
It is useful for the prevention of tonic-clonic seizures (also known as grand mal seizures) and focal seizures, but not absence seizures
Adults—At first, 5 milliliters (mL) or one teaspoonful 3 times a day
30 mg; 100 mg; Capsule, extended-release
However, serum drug levels should only be taken when there is a clear indication to guide patient A 15-mg/kg dose of i
, hypotension, ataxia, nausea, vomiting, apnea, nystagmus), the patient's age, the
IV infusion should not exceed 50 mg/min in adults or 1-3 mg/kg/min (or 50 mg/min, whichever is slower) Dosage forms: ER CAP: 30 mg, 100 mg; CHEWABLE: 50 mg; SUSP: 125 mg per 5 mL
The solution is in a vehicle containing 40% propylene glycol and 10% alcohol in water for injection, adjusted to pH 12 with sodium hydroxide
Intravenous: When fosphenytoin is administered by IV infusion, maximum plasma fosphenytoin concentrations are achieved at the end of the infusion
This appears to be dose-dependent
Serious arrhythmias require intravenous treatment in intermittent doses of 2 mg/kg administered over 3–5 min to prevent hypotension and cardiac arrest from the propylene glycol vehicle
The first dose should be given 12–24 hours after the loading dose
Rationalise dose to single daily dose to prevent unnecessary loss of feed time
In non-urgent situations where it is necessary to administer maintenance doses via the intravenous route (i
Dosage adjustment of the corticosteroid may be necessary when phenytoin is added to or withdrawn from concomitant therapy